{ "format" : "linked-data-api", "version" : "0.2", "result" : {"_about" : "https://eldaddp.azurewebsites.net/answeredquestions.text?houseId=2&AnswerDate=2024-03-25®isteredInterest=false&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "definition" : "https://eldaddp.azurewebsites.net/meta/answeredquestions.text?houseId=2&AnswerDate=2024-03-25®isteredInterest=false&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "extendedMetadataVersion" : "https://eldaddp.azurewebsites.net/answeredquestions.text?houseId=2&AnswerDate=2024-03-25®isteredInterest=false&_metadata=all&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "first" : "https://eldaddp.azurewebsites.net/answeredquestions.text?_page=0&houseId=2&AnswerDate=2024-03-25®isteredInterest=false&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "hasPart" : "https://eldaddp.azurewebsites.net/answeredquestions.text?houseId=2&AnswerDate=2024-03-25®isteredInterest=false&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "isPartOf" : "https://eldaddp.azurewebsites.net/answeredquestions.text?houseId=2&AnswerDate=2024-03-25®isteredInterest=false&min-ddpModified.=2024-03-25T18%3A11%3A09.464Z", "items" : [{"_about" : "http://data.parliament.uk/resources/1694864", "AnsweringBody" : [{"_value" : "Department of Health and Social Care"} ], "answer" : {"_about" : "http://data.parliament.uk/resources/1694864/answer", "answerText" : {"_value" : "

The following table shows the total number of items issued for mirtazapine, each year since 2014 to 2023:<\/p>

Time Period<\/p><\/td>

Total items issued<\/p><\/td><\/tr>

2014<\/p><\/td>

6,056,918<\/p><\/td><\/tr>

2015<\/p><\/td>

6,783,906<\/p><\/td><\/tr>

2016<\/p><\/td>

7,526,200<\/p><\/td><\/tr>

2017<\/p><\/td>

8,198,345<\/p><\/td><\/tr>

2018<\/p><\/td>

8,938,362<\/p><\/td><\/tr>

2019<\/p><\/td>

9,702,599<\/p><\/td><\/tr>

2020<\/p><\/td>

10,532,577<\/p><\/td><\/tr>

2021<\/p><\/td>

11,249,963<\/p><\/td><\/tr>

2022<\/p><\/td>

11,776,025<\/p><\/td><\/tr>

2023<\/p><\/td>

12,401,593<\/p><\/td><\/tr><\/tbody><\/table>

Source: Data was provided by the NHS Business Services Authority, using the British National Formulary chemical substance mirtazapine<\/p>

Note: Items have been dispensed, but not necessarily prescribed, in England.<\/p>

The Medicines and Healthcare products Regulatory Agency (MHRA) is responsible for ensuring medicines, medical devices, and blood components for transfusion meet applicable standards of safety, quality, and efficacy. The MHRA rigorously assesses available data, including from the Yellow Card scheme, and seeks advice from their independent advisory committee, the Commission on Human Medicines, where appropriate to inform regulatory decisions.<\/p>

The MHRA has received a total of 46 Yellow Card reports of sexual dysfunction related reactions suspected to be associated with mirtazapine, four of which include information that suggest the suspected adverse reactions persisted after mirtazapine was withdrawn. The following table shows the number of Yellow Card reports of suspected mirtazapine related sexual dysfunction, and reports of sexual dysfunction that persisted after the drug was withdrawn, each year from 2014 to 2024:<\/p>

Year<\/p><\/td>

Reports of sexual dysfunction<\/p><\/td>

Reports of sexual dysfunction that continued after mirtazapine was withdrawn<\/p><\/td><\/tr>

2014<\/p><\/td>

3<\/p><\/td>

0<\/p><\/td><\/tr>

2015<\/p><\/td>

1<\/p><\/td>

0<\/p><\/td><\/tr>

2016<\/p><\/td>

2<\/p><\/td>

0<\/p><\/td><\/tr>

2017<\/p><\/td>

3<\/p><\/td>

0<\/p><\/td><\/tr>

2018<\/p><\/td>

1<\/p><\/td>

0<\/p><\/td><\/tr>

2019<\/p><\/td>

5<\/p><\/td>

1<\/p><\/td><\/tr>

2020<\/p><\/td>

3<\/p><\/td>

0<\/p><\/td><\/tr>

2021<\/p><\/td>

5<\/p><\/td>

1<\/p><\/td><\/tr>

2022<\/p><\/td>

10<\/p><\/td>

1<\/p><\/td><\/tr>

2023<\/p><\/td>

9<\/p><\/td>

0<\/p><\/td><\/tr>

2024<\/p><\/td>

4<\/p><\/td>

1<\/p><\/td><\/tr><\/tbody><\/table>

Source: data provided by the MHRA.<\/p>

It is important to note that the inclusion of a particular report on the MHRA\u2019s system does not necessarily mean that the adverse reactions reported have been caused by the suspect drug. Additionally, the number of reports received should not be used as a basis for determining the incidence of a reaction, as neither the total number of reactions occurring, nor the number of patients using the drug, is known.<\/p>

The MHRA continuously monitors the safety of medicines on the United Kingdom\u2019s market, including mirtazapine. Reports of suspected adverse reactions are reviewed weekly by a multidisciplinary team as part of the MHRA\u2019s signal detection process. The term signal is used to define any suspected adverse reaction or potential safety concern that requires further evaluation.<\/p>

Responsibility for adding a side effect to the product information leaflet sits with the MHRA. The product information for mirtazapine reflects the data currently available, and does not include sexual dysfunction as a possible side effect. However, data from Yellow Card reports and other sources such as published studies and periodic safety assessments are kept under continuous review by the MHRA. The marketing authorisation holder has recently submitted the latest periodic safety update report to the MHRA, and this will be carefully assessed. If there is sufficient evidence and associated data about the potential to experience sexual dysfunction as a side effect, the patient information for mirtazapine can be updated.<\/p>"} , "answeringMember" : {"_about" : "http://data.parliament.uk/members/4948", "label" : {"_value" : "Biography information for Lord Markham"} } , "answeringMemberPrinted" : {"_value" : "Lord Markham"} , "dateOfAnswer" : {"_value" : "2024-03-26", "_datatype" : "dateTime"} , "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"} , "questionFirstAnswered" : [{"_value" : "2024-03-26T14:30:21.317Z", "_datatype" : "dateTime"} ]} , "answeringDeptId" : {"_value" : "17"} , "answeringDeptShortName" : {"_value" : "Health and Social Care"} , "answeringDeptSortName" : {"_value" : "Health and Social Care"} , "date" : {"_value" : "2024-03-11", "_datatype" : "dateTime"} , "hansardHeading" : {"_value" : "Mirtazapine"} , "houseId" : {"_value" : "2"} , "legislature" : [{"_about" : "http://data.parliament.uk/terms/25277", "prefLabel" : {"_value" : "House of Lords"} } ], "questionText" : "To ask His Majesty's Government how many prescriptions for mirtazapine were issued in each year since 2014; how many Yellow Card reports of sexual dysfunction and persistent sexual dysfunction the MHRA received for mirtazapine in each year since 2014; and what consideration NHS England has given to adding sexual dysfunction as a side effect on the patient information leaflets for mirtazapine.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"} , "tablingMember" : {"_about" : "http://data.parliament.uk/members/738", "label" : {"_value" : "Biography information for Lord Alton of Liverpool"} } , "tablingMemberPrinted" : [{"_value" : "Lord Alton of Liverpool"} ], "uin" : "HL3163"} , {"_about" : "http://data.parliament.uk/resources/1694867", "AnsweringBody" : [{"_value" : "Women and Equalities"} ], "answer" : {"_about" : "http://data.parliament.uk/resources/1694867/answer", "answerText" : {"_value" : "

As has been the case under successive administrations, the Government does not publish granular details of Ministerial meetings or discussions.<\/p>"} , "answeringMember" : {"_about" : "http://data.parliament.uk/members/4703", "label" : {"_value" : "Biography information for Baroness Barran"} } , "answeringMemberPrinted" : {"_value" : "Baroness Barran"} , "dateOfAnswer" : {"_value" : "2024-03-25", "_datatype" : "dateTime"} , "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"} , "questionFirstAnswered" : [{"_value" : "2024-03-25T17:39:17.17Z", "_datatype" : "dateTime"} ]} , "answeringDeptId" : {"_value" : "31"} , "answeringDeptShortName" : {"_value" : "Women and Equalities"} , "answeringDeptSortName" : {"_value" : "Women and Equalities"} , "date" : {"_value" : "2024-03-11", "_datatype" : "dateTime"} , "hansardHeading" : {"_value" : "Equality and Human Rights Commission"} , "houseId" : {"_value" : "2"} , "legislature" : [{"_about" : "http://data.parliament.uk/terms/25277", "prefLabel" : {"_value" : "House of Lords"} } ], "questionText" : "To ask His Majesty's Government on which dates since 24 July 2018 the Minister for Women and Equalities contacted officers or board members of the Equality and Human Rights Commission and discussed the Commission\u2019s operational matters; in each case, what operational matters were discussed, and what were the outcomes of those discussions.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"} , "tablingMember" : {"_about" : "http://data.parliament.uk/members/2501", "label" : {"_value" : "Biography information for Baroness Barker"} } , "tablingMemberPrinted" : [{"_value" : "Baroness Barker"} ], "uin" : "HL3166"} , {"_about" : "http://data.parliament.uk/resources/1694889", "AnsweringBody" : [{"_value" : "Women and Equalities"} ], "answer" : {"_about" : "http://data.parliament.uk/resources/1694889/answer", "answerText" : {"_value" : "

The most recent data available on UK ethnicity pay gaps is for 2022. The adjusted pay gaps for the most recent 5 years (2018 to 2022) for the Bangladeshi, Pakistani and Caribbean ethnic groups are provided below. A positive percentage value for the ethnicity pay gap means that the relevant ethnic group earns less than the white reference group.<\/p>

<\/p>

Adjusted Ethnicity Pay Gaps<\/p><\/td>

Bangladeshi<\/p><\/td>

Pakistani<\/p><\/td>

Caribbean<\/p><\/td><\/tr>

2022<\/p><\/td>

UK born 8.3% Non UK born 17.4%<\/p><\/td>

UK born estimate considered unreliable (-2.0%) Non UK born 14.1%<\/p><\/td>

UK born 3.3% Non UK born 4.7%<\/p><\/td><\/tr>

2021<\/p><\/td>

UK born 18.3% Non UK born 20.4%<\/p><\/td>

UK born 9.5% Non UK born 11.9%<\/p><\/td>

UK born 8.0% Non UK born 10.5%<\/p><\/td><\/tr>

2020<\/p><\/td>

UK born 3.5% Non UK born 22.6%<\/p><\/td>

UK born 12.1% Non UK born 20.8%<\/p><\/td>

UK born 4.2% Non UK born estimate considered unreliable (3.7%)<\/p><\/td><\/tr>

2019<\/p><\/td>

UK born 7.0% Non UK born 20.6%<\/p><\/td>

UK born 3.2% Non UK born 16.0%<\/p><\/td>

UK born 6.3% Non UK born 11.9%<\/p><\/td><\/tr>

2018<\/p><\/td>

UK born 9.7% Non UK born 28.7%<\/p><\/td>

UK born 6.1% Non UK born 14.7%<\/p><\/td>

UK born 7.5% Non UK born 9.4%<\/p><\/td><\/tr><\/tbody><\/table>

<\/p>

Adjusted pay gaps account for a variety of pay determining characteristics such as occupation, age, sex and geographical region. These figures are split into UK and non-UK born as we do not have the overall adjusted pay gap available for these specific ethnic groups. Further data on ethnicity pay gaps is available from the ONS website at https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/earningsandworkinghours/articles/ethnicitypaygapsingreatbritain/2012to2022/relateddata<\/a>.<\/p>

<\/p>

Closing ethnicity pay gaps requires much wider shifts in society. Our ambitious Inclusive Britain strategy, published in March 2022, set out 74 bold actions to tackle entrenched ethnic disparities in employment, education, health and criminal justice. This includes our comprehensive guidance for employers on ethnicity pay reporting, published last April, which set out best practice on measuring, analysing and reporting ethnicity pay gaps. We also launched an Inclusion at Work Panel last year aimed at helping employers achieve fairness and inclusion in the workplace.<\/p>

<\/p>"} , "answeringMember" : {"_about" : "http://data.parliament.uk/members/4703", "label" : {"_value" : "Biography information for Baroness Barran"} } , "answeringMemberPrinted" : {"_value" : "Baroness Barran"} , "dateOfAnswer" : {"_value" : "2024-04-26", "_datatype" : "dateTime"} , "groupedQuestionUIN" : {"_value" : "HL3189"} , "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"} , "questionFirstAnswered" : [{"_value" : "2024-04-26T14:00:42.917Z", "_datatype" : "dateTime"} ]} , "answeringDeptId" : {"_value" : "31"} , "answeringDeptShortName" : {"_value" : "Women and Equalities"} , "answeringDeptSortName" : {"_value" : "Women and Equalities"} , "date" : {"_value" : "2024-03-11", "_datatype" : "dateTime"} , "hansardHeading" : {"_value" : "Equal Pay: Ethnic Groups"} , "houseId" : {"_value" : "2"} , "legislature" : [{"_about" : "http://data.parliament.uk/terms/25277", "prefLabel" : {"_value" : "House of Lords"} } ], "questionText" : "To ask His Majesty's Government what assessment they have made of progress made towards closing (1) the overall ethnicity pay gap, and (2) the ethnicity pay gap, for (a) people of Bangladeshi heritage, (b) people of Pakistani heritage, and (c) people of African Caribbean heritage.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"} , "tablingMember" : {"_about" : "http://data.parliament.uk/members/4557", "label" : {"_value" : "Biography information for Lord Shinkwin"} } , "tablingMemberPrinted" : [{"_value" : "Lord Shinkwin"} ], "uin" : "HL3188"} , {"_about" : "http://data.parliament.uk/resources/1694890", "AnsweringBody" : [{"_value" : "Women and Equalities"} ], "answer" : {"_about" : "http://data.parliament.uk/resources/1694890/answer", "answerText" : {"_value" : "

The most recent data available on UK ethnicity pay gaps is for 2022. The adjusted pay gaps for the most recent 5 years (2018 to 2022) for the Bangladeshi, Pakistani and Caribbean ethnic groups are provided below. A positive percentage value for the ethnicity pay gap means that the relevant ethnic group earns less than the white reference group.<\/p>

<\/p>

Adjusted Ethnicity Pay Gaps<\/p><\/td>

Bangladeshi<\/p><\/td>

Pakistani<\/p><\/td>

Caribbean<\/p><\/td><\/tr>

2022<\/p><\/td>

UK born 8.3% Non UK born 17.4%<\/p><\/td>

UK born estimate considered unreliable (-2.0%) Non UK born 14.1%<\/p><\/td>

UK born 3.3% Non UK born 4.7%<\/p><\/td><\/tr>

2021<\/p><\/td>

UK born 18.3% Non UK born 20.4%<\/p><\/td>

UK born 9.5% Non UK born 11.9%<\/p><\/td>

UK born 8.0% Non UK born 10.5%<\/p><\/td><\/tr>

2020<\/p><\/td>

UK born 3.5% Non UK born 22.6%<\/p><\/td>

UK born 12.1% Non UK born 20.8%<\/p><\/td>

UK born 4.2% Non UK born estimate considered unreliable (3.7%)<\/p><\/td><\/tr>

2019<\/p><\/td>

UK born 7.0% Non UK born 20.6%<\/p><\/td>

UK born 3.2% Non UK born 16.0%<\/p><\/td>

UK born 6.3% Non UK born 11.9%<\/p><\/td><\/tr>

2018<\/p><\/td>

UK born 9.7% Non UK born 28.7%<\/p><\/td>

UK born 6.1% Non UK born 14.7%<\/p><\/td>

UK born 7.5% Non UK born 9.4%<\/p><\/td><\/tr><\/tbody><\/table>

<\/p>

Adjusted pay gaps account for a variety of pay determining characteristics such as occupation, age, sex and geographical region. These figures are split into UK and non-UK born as we do not have the overall adjusted pay gap available for these specific ethnic groups. Further data on ethnicity pay gaps is available from the ONS website at https://www.ons.gov.uk/employmentandlabourmarket/peopleinwork/earningsandworkinghours/articles/ethnicitypaygapsingreatbritain/2012to2022/relateddata<\/a>.<\/p>

<\/p>

Closing ethnicity pay gaps requires much wider shifts in society. Our ambitious Inclusive Britain strategy, published in March 2022, set out 74 bold actions to tackle entrenched ethnic disparities in employment, education, health and criminal justice. This includes our comprehensive guidance for employers on ethnicity pay reporting, published last April, which set out best practice on measuring, analysing and reporting ethnicity pay gaps. We also launched an Inclusion at Work Panel last year aimed at helping employers achieve fairness and inclusion in the workplace.<\/p>

<\/p>"} , "answeringMember" : {"_about" : "http://data.parliament.uk/members/4703", "label" : {"_value" : "Biography information for Baroness Barran"} } , "answeringMemberPrinted" : {"_value" : "Baroness Barran"} , "dateOfAnswer" : {"_value" : "2024-03-25", "_datatype" : "dateTime"} , "groupedQuestionUIN" : {"_value" : "HL3188"} , "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"} , "questionFirstAnswered" : [{"_value" : "2024-03-25T14:00:42.95Z", "_datatype" : "dateTime"} ]} , "answeringDeptId" : {"_value" : "31"} , "answeringDeptShortName" : {"_value" : "Women and Equalities"} , "answeringDeptSortName" : {"_value" : "Women and Equalities"} , "date" : {"_value" : "2024-03-11", "_datatype" : "dateTime"} , "hansardHeading" : {"_value" : "Equal Pay: Ethnic Groups"} , "houseId" : {"_value" : "2"} , "legislature" : [{"_about" : "http://data.parliament.uk/terms/25277", "prefLabel" : {"_value" : "House of Lords"} } ], "questionText" : "To ask His Majesty's Government whether they have a timeframe for closing (1) the overall ethnicity pay gap, and (2) the ethnicity pay gap, for (a) people of Bangladeshi heritage, (b) people of Pakistani heritage, and (c) people of African Caribbean heritage.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"} , "tablingMember" : {"_about" : "http://data.parliament.uk/members/4557", "label" : {"_value" : "Biography information for Lord Shinkwin"} } , "tablingMemberPrinted" : [{"_value" : "Lord Shinkwin"} ], "uin" : "HL3189"} ], "itemsPerPage" : 10, "page" : 0, "startIndex" : 1, "totalResults" : 4, "type" : ["http://purl.org/linked-data/api/vocab#ListEndpoint", "http://purl.org/linked-data/api/vocab#Page"]} }