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<p>The numbers needed to vaccinate (NNV) for the prevention of hospitalisation was
calculated to consider the benefits of continued offers of primary vaccination, booster
vaccination, the autumn booster and potential boosting in the spring of 2023, for
example, for those newly entering a risk group. This calculation estimates the number
of people in a particular group who would need to be vaccinated in order to prevent
one hospitalisation. The lower the number, the more beneficial vaccination of that
group would be.</p><p> </p><p>Strong age effects were seen, as well as large differences
within adult ages, by clinical risk group. The oldest age groups and the older individuals
in clinical risk groups had the lowest NNV for prevention of hospitalisation. There
is also a trend for higher NNV for prevention of hospitalisation when moving from
the primary to each booster dose.</p><p> </p><p>The spring 2023 booster is for immunosuppressed
people at risk rather than all individuals in a clinical risk group.</p><p> </p><p>The
results of NNV by age and clinical risk group are shown in Tables 3b and 4a of Appendix
1, which is attached.</p><p> </p><p>These cover all individuals in a risk group based
on analysis of data including the national immunisation register. The NNV has not
been broken down into separate clinical risk groups, as outlined in the Green Book.</p>
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