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<p>Mefloquine (brand name Lariam) is one of several drugs licensed for the prevention
(<strong>c</strong>hemoprophylaxis) or treatment of malaria. As with any medicine,
mefloquine may cause side effects in some people and the potential risks should be
balanced against the expected benefits of therapy. Information on possible side effects
is available to the medical profession via the Summary of Product Characteristics
(SmPC), and to patients via the Patient Information Leaflet.</p><p> </p><p> </p><p>
</p><p>In 2013, the Medicines and Healthcare products Regulatory Agency (MHRA) strengthened
the warnings in the mefloquine SmPC, particularly regarding the well-established risk
of neuropsychiatric side effects. The licence holder (Roche) also issued a letter
to healthcare professionals at the end of October 2013 to increase awareness of these
possible risks, alongside a prescriber checklist and patient alert card to aid compliance
with the warnings. In November 2013, the MHRA issued a further communication to healthcare
professionals on the risks of mefloquine via its Drug Safety Update bulletin:</p><p>
</p><p> </p><p> </p><p>www.mhra.gov.uk/Safetyinformation/DrugSafetyUpdate/CON336723</p><p>
</p><p> </p><p> </p><p>As with all medicines, the MHRA will keep the safety of mefloquine
under continual review.</p><p> </p><p> </p><p> </p><p>The Advisory Committee for Malaria
Prevention (ACMP) carefully considered all available data following the Food and Drug
Administration’s safety communication and subsequent modification of the SmPC by Roche
in September 2013. SmPC recommendations for monitoring of liver function and eye assessment
in long term use have also been added to the guidelines. The ACMP continues to believe
that mefloquine is a valuable option for prophylaxis against malaria when appropriate
risk assessments are undertaken.</p><p> </p>
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