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1690562

registered interest
date	20/02/2024
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, how her Department plans to ensure that increases in funding lead to increased participation in clinical trials of people living with dementia.
tabling member constituency	Luton South
tabling member printed	Rachel Hopkins
uin	14989
answer	answer is ministerial correction date of answer 26/02/2024 answer text <p>The Government’s responsibility for delivering dementia research is shared between the Department of Health and Social Care, with research delivered by the National Institute for Health and Care Research (NIHR), and the Department for Science Innovation and Technology, with research delivered via UK Research and Innovation. The NIHR is investing in a range of activities to increase the participation of people living with dementia in clinical trials.</p><p>In January 2024, the NIHR announced the Dementia-Translational Research Collaboration Trials Network (D-TRC TN) which is supported by almost £50 million of funding over five years. This will expand the United Kingdom’s early phase clinical trial capabilities in dementia, speeding up the development of new treatments. The D-TRC-TN will increase opportunities for people with dementia to take part in clinical trials, irrespective of where they live in the UK. The NIHR also works in partnership with Alzheimer’s Research UK, the Alzheimer’s Society and Alzheimer’s Scotland to deliver and invest in Join Dementia Research, an online platform which enables the involvement of people with a dementia diagnosis, and their carers, to take part in a range of research, including clinical trials.</p><p> </p><p>The Department of Health and Social Care published the full response to the O’Shaughnessy Review into commercial clinical trials on 22 November 2023, integrating the response into the delivery of our vision to benefit all kinds of clinical research, including trials funded by medical research charities, as well as industry. This included the announcement of a Clinical Trials Delivery Accelerator focused on dementia, with up to £20 million of funding.</p> answering member constituency Pendle answering member printed Andrew Stephenson question first answered 26/02/2024 10:08:55 answering member 4044 label Biography information for Andrew Stephenson
tabling member	4873 label Biography information for Rachel Hopkins

1689479

registered interest
date	16/02/2024
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, what assessment her Department has made of the potential merits of increasing the participation of people living with Dementia in clinical trials.
tabling member constituency	Belfast South
tabling member printed	Claire Hanna
uin	14378
answer	answer is ministerial correction date of answer 22/02/2024 answer text <p>The National Institute for Health and Care Research (NIHR) is supporting a range of activities to increase the participation of people living with dementia in clinical trials.</p><p>In January 2024, the NIHR announced the Dementia-Translational Research Collaboration Trials Network (D-TRC TN) which is supported by almost £50 million of funding over five years. This will expand the United Kingdom’s early phase clinical trial capabilities in dementia, speeding up the development of new treatments. The D-TRC TN will increase opportunities for people with dementia to take part in clinical trials, irrespective of where they live in the UK. The NIHR also works in partnership with Alzheimer’s Research UK, Alzheimer’s Society and Alzheimer’s Scotland to deliver Join Dementia Research (JDR), an online platform which enables the involvement of people with a dementia diagnosis and their carers to take part in a range of research, including clinical trials. When volunteers register for JDR, the information they provide is used to match them to studies which are suitable for them to take part in, both online, nationally and in their local areas. Almost 10% of people registered on JDR have a dementia or mild cognitive impairment diagnosis.</p> answering member constituency Pendle answering member printed Andrew Stephenson question first answered 22/02/2024 14:14:06 answering member 4044 label Biography information for Andrew Stephenson
tabling member	4827 label Biography information for Claire Hanna

1670761

registered interest
date	17/11/2023
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, what steps her Department is taking to incentivise overseas researchers to undertake clinical trials on dementia research in the UK.
tabling member constituency	Linlithgow and East Falkirk
tabling member printed	Martyn Day
uin	2412
answer	answer is ministerial correction date of answer 22/11/2023 answer text <p>The Department, via the National Institute for Health and Care Research (NIHR), invests in world-class facilities, expertise and a skilled delivery workforce for clinical research in the National Health Service and wider health and care system. This infrastructure has been operational for many years as a centralised system, creating a unique offer in the United Kingdom for overseas researchers to undertake clinical trials, including in dementia. This includes the Dementia Translational Research Collaboration, which plays a critical role in coordinating UK dementia research in early phase clinical trials and the NIHR Clinical Research Network Dementias and Neurodegeneration Specialty, which supports patients, the public and health and care organisations across England to participate in dementia research spanning the full translational research pathway.</p><p>The multi-year Vision for the Future of UK Clinical Research Delivery was published on 23 March 2021 and sets out our ambition to create a patient-centred, pro-innovation and digitally enabled clinical research environment. The Government also commissioned Lord O’Shaughnessy to conduct a review into commercial clinical trials following a drop in the UK’s performance during and following the pandemic. The Government published the full response to the Lord O’Shaughnessy review on 22 November 2023. The response provides an update on the significant progress we have made in recovering clinical trial performance and set out our plan, backed by up to £121 million, to strengthen the clinical trials ecosystem and make it quicker and easier for NHS patients to access the latest innovative treatments through clinical research.</p> answering member constituency Pendle answering member printed Andrew Stephenson question first answered 22/11/2023 15:55:49 answering member 4044 label Biography information for Andrew Stephenson
tabling member	4488 label Biography information for Martyn Day

1668437

registered interest
date	08/11/2023
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, how the National Institute for Health and Care Research's Dementia Translational Research Collaborative plans to work with a Clinical Trial Acceleration Network for dementia to increase the UK’s share of clinical trials.
tabling member constituency	Newcastle upon Tyne Central
tabling member printed	Chi Onwurah
uin	799
answer	answer is ministerial correction date of answer 15/11/2023 answer text <p>The Dementia Translational Research Collaboration (D-TRC) is funded by the Department via the National Institute for Health &amp; Care Research. The D-TRC plays a critical role in coordinating dementia research in early phase clinical trials in the United Kingdom and seeks to offer a wider, more collaborative and cohesive network. The D-TRC's over-arching goal is the elevation of the UK as the world-leading place to conduct early phase clinical trials in dementia.</p><p>The Government will publish a full response to the Lord O’Shaughnessy independent review into commercial clinical trials in autumn 2023. The response will include an update on progress and implementation of the initial five headline commitments and foundational actions that the government made in May 2023 as well as all other recommendations in the review.</p> answering member constituency Pendle answering member printed Andrew Stephenson question first answered 15/11/2023 16:42:09 answering member 4044 label Biography information for Andrew Stephenson
tabling member	4124 label Biography information for Chi Onwurah

1507124

registered interest
date	20/09/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, how many phase (a) I, (b) II and (c) III dementia clinical trials have been hosted in England in each of the last ten years; and how many participants were recruited for each of those trials.
tabling member constituency	Harrow East
tabling member printed	Bob Blackman
uin	51608
answer	answer is ministerial correction date of answer 27/09/2022 answer text <p>The number of phase I, II and III dementia clinical trials supported by the National Institute for Health and Social Care Research’s Clinical Research Network in England in each of the last 10 years and the number of participants recruited is shown in the attached tables.</p> answering member constituency Newark answering member printed Robert Jenrick question first answered 27/09/2022 10:49:23 answering member 4320 label Biography information for Robert Jenrick attachment 1 file name PQ 51608 attachment.docx title NIHR-supported dementia clinical trials
tabling member	4005 label Biography information for Bob Blackman

1506237

registered interest
date	08/09/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, how many (a) phase I, (b) phase II and (c) phase III clinical trials for dementia have been hosted in Wales in each of the last 10 years.
tabling member constituency	Vale of Clwyd
tabling member printed	Dr James Davies
uin	49731
answer	answer is ministerial correction date of answer 22/09/2022 answer text <p>The information requested on clinical trials hosted in Wales and Scotland is not held centrally. A table showing the number of phase one, two and three clinical trials supported by the National Institute for Health and Social Care Research Clinical Research Network in England for dementia from 2012/13 to 2021/22 is attached.</p> answering member constituency Newark answering member printed Robert Jenrick grouped question UIN 49792 question first answered 22/09/2022 08:33:32 answering member 4320 label Biography information for Robert Jenrick attachment 1 file name Formatted TABLE PQ 49792 attachment.docx title Dementia clinical trials in England 2012 to 2022
tabling member	4476 label Biography information for Dr James Davies

1506247

registered interest
date	08/09/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, what recent discussions her Department has had with (a) BEIS, (b) NIHR and (c) the MHRA about the UK’s ability to host large multi-site clinical trials for dementia.
tabling member constituency	Central Ayrshire
tabling member printed	Dr Philippa Whitford
uin	49695
answer	answer is ministerial correction date of answer 23/09/2022 answer text <p>The Department of Health and Social Care is working with the Department for Business, Energy and Industrial Strategy and the National Institute for Health and Care Research to support the delivery of the Dame Barbara Windsor Dementia Mission, led by the Office for Life Sciences. The Mission will accelerate the development of novel ‘precision’ treatments in neurodegeneration and increase the number of clinical trials, including large multi-site clinical trials. The Office for Life Sciences has had held initial discussions with the Medicines and Healthcare products Regulatory Agency on the Mission.</p> answering member constituency Harborough answering member printed Neil O'Brien question first answered 23/09/2022 08:32:49 answering member 4679 label Biography information for Neil O'Brien
tabling member	4385 label Biography information for Dr Philippa Whitford

1506384

registered interest
date	08/09/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care how many (a) phase one, (b) phase two and (c) phase three clinical trials for dementia treatments have taken place in (i) England, (ii) Wales, and (iii) Scotland in each of the past 10 years.
tabling member constituency	Kirkcaldy and Cowdenbeath
tabling member printed	Neale Hanvey
uin	49792
answer	answer is ministerial correction date of answer 22/09/2022 answer text <p>The information requested on clinical trials hosted in Wales and Scotland is not held centrally. A table showing the number of phase one, two and three clinical trials supported by the National Institute for Health and Social Care Research Clinical Research Network in England for dementia from 2012/13 to 2021/22 is attached.</p> answering member constituency Newark answering member printed Robert Jenrick grouped question UIN 49731 question first answered 22/09/2022 08:33:32 answering member 4320 label Biography information for Robert Jenrick attachment 1 file name Formatted TABLE PQ 49792 attachment.docx title Dementia clinical trials in England 2012 to 2022
tabling member	4782 label Biography information for Neale Hanvey

1506387

registered interest
date	08/09/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health and Social Care, what further measures she will take to raise awareness of the importance of (a) improving the clinical research infrastructure in the UK; and (b) increasing clinical trial participation in relation to the development of new treatments for dementia.
tabling member constituency	Kirkcaldy and Cowdenbeath
tabling member printed	Neale Hanvey
uin	49793
answer	answer is ministerial correction date of answer 27/09/2022 answer text <p>‘Saving and Improving Lives: The Future of UK Clinical Research Delivery’, published in March 2021, sets out the ambition to create people-centred, pro-innovation and digitally enabled clinical research infrastructure. ‘The Future of UK Clinical Research Delivery: 2022 to 2025 implementation plan’, published on 30 June 2022, summarises the actions we will take over the next three years.</p><p>The platform Join Dementia Research, funded and delivered by the Departmentally funded National Institute for Health and Care Research with Alzheimer’s Society, Alzheimer Scotland and Alzheimer’s Research UK, allows people to register an interest in dementia research and be matched to trials. This aims to improve participation and diversity in dementia research.</p> answering member constituency Newark answering member printed Robert Jenrick question first answered 27/09/2022 11:14:16 answering member 4320 label Biography information for Robert Jenrick
tabling member	4782 label Biography information for Neale Hanvey

1460488

registered interest
date	26/04/2022
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia: Clinical Trials
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government what recent discussions they have had with (1) the Medicines and Healthcare products Regulatory Agency, and (2) the National Institute for Health and Care Research, about which lessons from the success of COVID-19 trials could be applied to improve the (a) approval, and (b) set-up process, for dementia trials.
tabling member printed	Lord McColl of Dulwich
uin	HL7972
answer	answer is ministerial correction date of answer 28/04/2022 answer text It has not proved possible to respond to this question in the time available before Prorogation. Ministers will correspond directly with the Member. answering member printed Lord Kamall question first answered 28/04/2022 10:55:28 answering member 4909 label Biography information for Lord Kamall
tabling member	1892 label Biography information for Lord McColl of Dulwich