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<p>The Medicines and Healthcare products Regulatory Agency (MHRA) encourages anyone
to report a suspected adverse reaction (ADR) to a vaccine or medicine through the
Yellow Card Scheme:</p><p> </p><p><a href="http://www.mhra.gov.uk/yellowcard" target="_blank">www.mhra.gov.uk/yellowcard</a></p><p>A
Yellow Card report is not proof of a side effect occurring, but a suspicion by the
reporter that the vaccine or medicine may have been the cause. Such reports are kept
under continual review to identify potential new risks.</p><p> </p><p>Between 31 October
2014 – 30 October 2017 a total of 649 serious suspected adverse reaction (ADR) reports
with human papilloma virus (HPV) vaccines have been reported to the Medicines and
Healthcare products Regulatory Agency (MHRA) via the Yellow Card Scheme (data run
date: 1 November 2017). In this three year period, at least 1 million doses of HPV
vaccine were administered in the United Kingdom.</p><p> </p><p>A breakdown of UK serious
suspected spontaneous ADR reports received via the Yellow Card Scheme beween 31 October
2014 – 30 October 2016 by brand and year received is shown in the following table.</p><p>
</p><table><tbody><tr><td><p>HPV Vaccine</p></td><td><p>Number of serious reports</p></td></tr><tr><td><p>HPV
brand unspecified</p></td><td><p>181</p></td></tr><tr><td><p>Cervarix</p></td><td><p>64</p></td></tr><tr><td><p>Gardasil</p></td><td><p>390</p></td></tr><tr><td><p>Gardasil
9</p></td><td><p>18</p></td></tr><tr><td><p>Total</p></td><td><p>649</p></td></tr></tbody></table><p>
</p><p>Source: MHRA sentinel database for adverse reactions</p><p> </p><p>Notes:</p><p>
</p><p>The total number of reports received by vaccine brand is not equal to the totals
in the table above as some reports included more than one HPV vaccine brand.</p><p>
</p><p>The MHRA has received a total of 3,159 serious suspected adverse reaction reports
associated with HPV vaccine (data run date 1 November 2017).</p><p> </p><p>All serious
reports received via the Yellow Card Scheme are reviewed based on the details received
from the reporter. Follow up letters may be sent for missing information such as vaccine
brand name, batch number, medical history, results of investigations, diagnoses and
details of outcome.</p><p> </p><p>The Commission on Human Medicines has thoroughly
reviewed the safety of HPV vaccines and concluded that the evidence does not support
a link between HPV vaccination and the development of chronic illnesses.</p>
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