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1012109

registered interest
date	21/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Ovarian Hyperstimulation Syndrome
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government, further to the Written Answers by Lord O'Shaughnessy on 15 November (HL11187 and HL11188), how many emergency and out-of-hours admissions due to ovarian hyperstimulation syndrome (OHSS) were reported to the Human Fertilisation and Embryology Authority in the last five years for which figures are available; what evidence supports their view that some OHSS-related admissions may have been incorrectly coded in the Hospital Episode Statistics; how many such admissions they estimate have been incorrectly coded in the last five years for which figures are available; and what steps they are taking to ensure that OHSS-related admissions are correctly recorded.
tabling member printed	Lord Alton of Liverpool
uin	HL11636
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that it is a requirement for all its licensed centres to report cases of ovarian hyperstimulation syndrome (OHSS) that require a hospital admission and have a severity grading of severe or critical. Some centres also report cases of mild or moderate OHSS.</p><p>Between 1 October 2013 and 31 October 2018 there were 792 OHSS cases reported requiring hospital admission (391 of which were classified as severe and 401 classified as mild/moderate). HFEA does not hold data on whether these admissions were out of hours or via emergency admission. Following the reports of cases of severe or critical OHSS, the centres are required to conduct a root cause analysis and submit a report to the HFEA. The HFEA publishes an annual report on incidents, of which OHSS cases form a part.</p><p>From April 2018 the HFEA has required its licensed centres to provide it with more information about treatment provided to patients in cases of severe OHSS. This information will be collected for two years and will then be analysed.</p><p>The HFEA has also advised that following discussions with key stakeholders it has reached a view that the Hospital Episode Statistics data may include a mislabelling of cases of OHSS. A paper presented to Authority members in January 2018 sets out the work undertaken to examine the reporting of severe and critical OHSS. A copy of <em>Ovarian Hyperstimulation Syndrome</em> is attached. HFEA does not hold estimates of the number of hospital admissions that may have been incorrectly coded for OHSS.</p><p>HFEA is continuing to work to better understand the incidence of OHSS, reduce its occurrence and improve reporting.</p><p><strong> </strong></p> answering member printed Lord O'Shaughnessy grouped question UIN HL11637 question first answered 03/12/2018 15:12:37 answering member 4545 label Biography information for Lord O'Shaughnessy attachment 1 file name 2018-01-24 - Authority paper - item 10 - Ovarian hyperstimulation syndrome - FINAL.doc title OHSS Authority paper
tabling member	738 label Biography information for Lord Alton of Liverpool

1012110

registered interest
date	21/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Ovarian Hyperstimulation Syndrome
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government, further to the Written Answers by Lord O'Shaughnessy on 15 November (HL11187 and HL11188), how many emergency and out-of-hours admissions due to Ovarian Hyperstimulation Syndrome were investigated by the Human Fertilisation and Embryology Authority in the last five years for which figures are available; whether any such investigations resulted in published reports; and if so, where such reports are available.
tabling member printed	Lord Alton of Liverpool
uin	HL11637
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that it is a requirement for all its licensed centres to report cases of ovarian hyperstimulation syndrome (OHSS) that require a hospital admission and have a severity grading of severe or critical. Some centres also report cases of mild or moderate OHSS.</p><p>Between 1 October 2013 and 31 October 2018 there were 792 OHSS cases reported requiring hospital admission (391 of which were classified as severe and 401 classified as mild/moderate). HFEA does not hold data on whether these admissions were out of hours or via emergency admission. Following the reports of cases of severe or critical OHSS, the centres are required to conduct a root cause analysis and submit a report to the HFEA. The HFEA publishes an annual report on incidents, of which OHSS cases form a part.</p><p>From April 2018 the HFEA has required its licensed centres to provide it with more information about treatment provided to patients in cases of severe OHSS. This information will be collected for two years and will then be analysed.</p><p>The HFEA has also advised that following discussions with key stakeholders it has reached a view that the Hospital Episode Statistics data may include a mislabelling of cases of OHSS. A paper presented to Authority members in January 2018 sets out the work undertaken to examine the reporting of severe and critical OHSS. A copy of <em>Ovarian Hyperstimulation Syndrome</em> is attached. HFEA does not hold estimates of the number of hospital admissions that may have been incorrectly coded for OHSS.</p><p>HFEA is continuing to work to better understand the incidence of OHSS, reduce its occurrence and improve reporting.</p><p><strong> </strong></p> answering member printed Lord O'Shaughnessy grouped question UIN HL11636 question first answered 03/12/2018 15:12:37 answering member 4545 label Biography information for Lord O'Shaughnessy attachment 1 file name 2018-01-24 - Authority paper - item 10 - Ovarian hyperstimulation syndrome - FINAL.doc title OHSS Authority paper
tabling member	738 label Biography information for Lord Alton of Liverpool

1011239

registered interest
date	20/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	IVF: Drugs
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government, further to the Written Answers by Lord O’Shaughnessy on 15 November (HL11187 and HL11188), what data are recorded by the Medicines and Healthcare products Regulatory Agency’s pharmacovigilance work and the Yellow Card Scheme regarding drugs and dosages administered to women during IVF treatment and early pregnancy; to what extent this includes off-label drugs in order to monitor their long-term effects on women undergoing IVF treatment; how this compares to the collection of such data in other countries; and why the Human Fertilisation and Embryology Authority has no plans to establish a central database to monitor the long-term health implications of the medicines administered to women during IVF.
tabling member printed	Lord Alton of Liverpool
uin	HL11600
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>The Medicines and Healthcare products Regulatory Agency (MHRA) continuously monitors all reports of suspected adverse drug reactions (ADRs) via the Yellow Card Scheme, including those reported in association with use for assisted reproduction such as in vitro fertilisation (IVF). These include reports of licensed and off-label use of medicines to suppress the natural menstrual cycle, medicines to prepare and stimulate the ovaries for ovulation, medicines at the time of egg collection and embryo transfer and medicines used to support the placenta during early pregnancy. The doses of each medicine used are set out in the product information of licensed medicines and are considered as part of the evaluation process when a potential safety concern is reviewed. A suspected ADR may be reported at any time after the medicine has been taken.</p><p>European Union legislation requires Member States to provide spontaneous reporting systems for ADRs to medicines. Such systems are widely used internationally for collection of suspected adverse reactions.</p><p>Data from the register of patients and treatments, maintained by the Human Fertilisation and Embryology Authority (HFEA), is already used for research on the long-term health implications of medicines administered during IVF. Among the research projects that have been conducted using HFEA register data are studies that looked at the cancer risk for women undergoing fertility treatment and children born as a result of assisted reproduction.</p> answering member printed Lord O'Shaughnessy question first answered 03/12/2018 15:14:43 answering member 4545 label Biography information for Lord O'Shaughnessy
tabling member	738 label Biography information for Lord Alton of Liverpool

1010093

registered interest
date	19/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia and Parkinson's Disease
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government how much they spent in total in providing medical treatment, social support, and financial assistance for sufferers of Alzheimer's, dementia, Parkinson's, and other related conditions, in the last year for which figures are available.
tabling member printed	Lord Alton of Liverpool
uin	HL11540
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>Data on the total spent by Government on providing medical treatment, social support and financial assistance for people with Alzheimer’s disease, dementia, Parkinson’s or other related conditions is not collected or reported centrally.</p><p>In the <em>Challenge on Dementia 2020</em>, the Government committed to double spending on dementia research to £300 million between 2015 and 2020. This is equivalent to around £60 million per annum and we are on track to meet this pledge. In 2017/18 the Government spent £82.5 million on dementia research. Much of the investment is for research to better understand the nature of dementia, to inform development of future treatments and find ways to prevent the onset of the condition.</p><p>The following table shows Government spending on dementia research through the National Institute for Health Research (NIHR), Medical Research Council (MRC) and Economic and Social Research Council (ESRC).</p><p> </p><p> </p><p> </p><p> </p><p> </p><table><tbody><tr><td><p>£000s</p></td><td><p>NIHR</p></td><td><p>MRC</p></td><td><p>ESRC</p></td><td><p>Total</p></td></tr><tr><td><p>2009-10</p></td><td><p>12,678</p></td><td><p>14,800</p></td><td><p>800</p></td><td><p>28,245</p></td></tr><tr><td><p>2010-11</p></td><td><p>18,612</p></td><td><p>16,800</p></td><td><p>1,400</p></td><td><p>36,456</p></td></tr><tr><td><p>2011-12</p></td><td><p>25,087</p></td><td><p>17,700</p></td><td><p>1,200</p></td><td><p>43,769</p></td></tr><tr><td><p>2012-13</p></td><td><p>25,556</p></td><td><p>25,300</p></td><td><p>2,500</p></td><td><p>52,249</p></td></tr><tr><td><p>2013-14</p></td><td><p>27,175</p></td><td><p>32,553</p></td><td><p>2,303</p></td><td><p>60,187</p></td></tr><tr><td><p>2014-15</p></td><td><p>31,483</p></td><td><p>23,968</p></td><td><p>3,333</p></td><td><p>58,373</p></td></tr><tr><td><p>2015-16</p></td><td><p>37,622</p></td><td><p>56,753</p></td><td><p>2,961</p></td><td><p>96,396</p></td></tr><tr><td><p>2016-17</p></td><td><p>44,623</p></td><td><p>36,000</p></td><td><p>2,490</p></td><td><p>83,113</p></td></tr><tr><td><p>2017-18</p></td><td><p>42,987</p></td><td><p>36,300</p></td><td><p>3,241</p></td><td><p>82,528</p></td></tr></tbody></table><p> </p><p> </p><p> </p><p> </p><p> </p><p><strong> </strong></p> answering member printed Lord O'Shaughnessy grouped question UIN HL11541 question first answered 03/12/2018 17:11:24 answering member 4545 label Biography information for Lord O'Shaughnessy
tabling member	738 label Biography information for Lord Alton of Liverpool

1010094

registered interest
date	19/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia and Parkinson's Disease
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government how much they spent in total in supporting direct research into finding effective treatments for the eradication of Alzheimer's, dementia, Parkinson's, and other related conditions, in the last year for which figures are available.
tabling member printed	Lord Alton of Liverpool
uin	HL11541
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>Data on the total spent by Government on providing medical treatment, social support and financial assistance for people with Alzheimer’s disease, dementia, Parkinson’s or other related conditions is not collected or reported centrally.</p><p>In the <em>Challenge on Dementia 2020</em>, the Government committed to double spending on dementia research to £300 million between 2015 and 2020. This is equivalent to around £60 million per annum and we are on track to meet this pledge. In 2017/18 the Government spent £82.5 million on dementia research. Much of the investment is for research to better understand the nature of dementia, to inform development of future treatments and find ways to prevent the onset of the condition.</p><p>The following table shows Government spending on dementia research through the National Institute for Health Research (NIHR), Medical Research Council (MRC) and Economic and Social Research Council (ESRC).</p><p> </p><p> </p><p> </p><p> </p><p> </p><table><tbody><tr><td><p>£000s</p></td><td><p>NIHR</p></td><td><p>MRC</p></td><td><p>ESRC</p></td><td><p>Total</p></td></tr><tr><td><p>2009-10</p></td><td><p>12,678</p></td><td><p>14,800</p></td><td><p>800</p></td><td><p>28,245</p></td></tr><tr><td><p>2010-11</p></td><td><p>18,612</p></td><td><p>16,800</p></td><td><p>1,400</p></td><td><p>36,456</p></td></tr><tr><td><p>2011-12</p></td><td><p>25,087</p></td><td><p>17,700</p></td><td><p>1,200</p></td><td><p>43,769</p></td></tr><tr><td><p>2012-13</p></td><td><p>25,556</p></td><td><p>25,300</p></td><td><p>2,500</p></td><td><p>52,249</p></td></tr><tr><td><p>2013-14</p></td><td><p>27,175</p></td><td><p>32,553</p></td><td><p>2,303</p></td><td><p>60,187</p></td></tr><tr><td><p>2014-15</p></td><td><p>31,483</p></td><td><p>23,968</p></td><td><p>3,333</p></td><td><p>58,373</p></td></tr><tr><td><p>2015-16</p></td><td><p>37,622</p></td><td><p>56,753</p></td><td><p>2,961</p></td><td><p>96,396</p></td></tr><tr><td><p>2016-17</p></td><td><p>44,623</p></td><td><p>36,000</p></td><td><p>2,490</p></td><td><p>83,113</p></td></tr><tr><td><p>2017-18</p></td><td><p>42,987</p></td><td><p>36,300</p></td><td><p>3,241</p></td><td><p>82,528</p></td></tr></tbody></table><p> </p><p> </p><p> </p><p> </p><p> </p><p><strong> </strong></p> answering member printed Lord O'Shaughnessy grouped question UIN HL11540 question first answered 03/12/2018 17:11:24 answering member 4545 label Biography information for Lord O'Shaughnessy
tabling member	738 label Biography information for Lord Alton of Liverpool

1010095

registered interest
date	19/11/2018
answering body	Department of Health and Social Care
answering dept id	17
answering dept short name	Health and Social Care
answering dept sort name	Health and Social Care
hansard heading	Dementia and Parkinson's Disease
house id	2
legislature	25277 pref label House of Lords
question text	To ask Her Majesty's Government what steps they have taken to form strategic global alliances with other governments, charitable organisations, and private companies to combine all available resources in finding effective treatments for the eradication of Alzheimer's, dementia, Parkinson's, and other related conditions.
tabling member printed	Lord Alton of Liverpool
uin	HL11542
answer	answer is ministerial correction date of answer 03/12/2018 answer text <p>Dementia remains a global challenge that we are committed to tackle in partnership with governments and organisations across the world.</p><p> </p><p>Following the first G8 Dementia Summit in December 2013, the United Kingdom has been leading international efforts to fight dementia and working with international partners such as the World Health Organization (WHO), the Organisation for Economic Cooperation and Development, the World Dementia Council and countries within the G7, European Union and beyond, to that end. In May 2017, the Government committed to support the WHO Global Plan of Action on Dementia, during the World Health Assembly.</p><p> </p><p>The UK is also part of ‘Act on Dementia’, a three-year European Union Joint Action to promote collaboration between members. As part of this work, the UK is leading a work package to support the development of dementia friendly communities across Europe.</p><p> </p><p>The Department co-founded the international Dementia Discovery Fund, the largest venture fund in the world focussed on funding research for a single disease area.</p> answering member printed Lord O'Shaughnessy question first answered 03/12/2018 15:13:35 answering member 4545 label Biography information for Lord O'Shaughnessy
tabling member	738 label Biography information for Lord Alton of Liverpool