As with all medicines in the United Kingdom, the Medicines and Healthcare products Regulatory Agency continuously monitors the safety of isotretinoin-containing medicines. This includes reports of suspected adverse drug reactions submitted by healthcare professionals, patients and carers through the Yellow Card scheme, as well as published and unpublished data. As new evidence on safety emerges it is carefully evaluated and, where appropriate, product information is updated and advice for prescribers and patients is issued.<\/p>
Specific assessments of possible psychiatric side effects associated with isotretinoin were considered by an Expert Working Group of the Commission on Human Medicines in 2005 and 2014. In addition, the risk of neuropsychiatric disorders was evaluated in a European review which was completed in 2018. This review concluded that the warnings in the product information for medicines containing isotretinoin regarding possible psychiatric adverse effects reflected what was known.<\/p>
Since 1998, warnings regarding the possible risk of developing depression and other psychiatric side effects have been included in the product information for Roaccutane and the generic versions of isotretinoin (the Summary of Product Characteristics for healthcare professionals and the patient information leaflet). The product information for isotretinoin warns that treatment may be associated with possible psychiatric side effects, that particular care needs to be taken in patients with a history of depression; and that all patients on isotretinoin should be monitored for signs of depression and referred for appropriate treatment if necessary. It also states that stopping isotretinoin may not lead to improvement and therefore further psychiatric or psychological evaluation may be necessary.<\/p>"} , "answeringMember" : {"_about" : "http://data.parliament.uk/members/4065", "label" : {"_value" : "Biography information for Dame Jackie Doyle-Price"} } , "answeringMemberConstituency" : {"_value" : "Thurrock"} , "answeringMemberPrinted" : {"_value" : "Jackie Doyle-Price"} , "dateOfAnswer" : {"_value" : "2019-05-22", "_datatype" : "dateTime"} , "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"} , "questionFirstAnswered" : [{"_value" : "2019-05-22T16:42:43.927Z", "_datatype" : "dateTime"} ]} , "answeringDeptId" : {"_value" : "17"} , "answeringDeptShortName" : {"_value" : "Health and Social Care"} , "answeringDeptSortName" : {"_value" : "Health and Social Care"} , "date" : {"_value" : "2019-05-17", "_datatype" : "dateTime"} , "hansardHeading" : {"_value" : "Isotretinoin: Side Effects"} , "houseId" : {"_value" : "1"} , "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"} } ], "questionText" : "To ask the Secretary of State for Health and Social Care, what assessment he has made of the potential health risks and psychiatric side-effects of the drug Roaccutane.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"} , "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"} } , "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"} , "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"} ], "uin" : "255661"} , {"_about" : "http://data.parliament.uk/resources/1127077", "AnsweringBody" : [{"_value" : "Department for Business, Energy and Industrial Strategy"} ], "answer" : {"_about" : "http://data.parliament.uk/resources/1127077/answer", "answerText" : {"_value" : "
Part 8 of the Enterprise Act 2008 provides for a number of enforcers, such as Trading Standards and the Competition and Markets Authority, to enforce consumer protection legislation, including the Consumer Protection from Unfair Trading Regulations 2008. Alleged breaches of legislation should be reported in the first instance through the Citizens Advice consumer service on 03454 04 05 06 (www.citizensadvice.org.uk/<\/a>). The helpline will refer on alleged breaches of legislation to the relevant authority for appropriate enforcement action.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4487", "label" : {"_value" : "Biography information for Kelly Tolhurst"}
}
, "answeringMemberConstituency" : {"_value" : "Rochester and Strood"}
, "answeringMemberPrinted" : {"_value" : "Kelly Tolhurst"}
, "dateOfAnswer" : {"_value" : "2019-05-21", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-21T14:54:53.487Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "201"}
, "answeringDeptShortName" : {"_value" : "Business, Energy and Industrial Strategy"}
, "answeringDeptSortName" : {"_value" : "Business, Energy and Industrial Strategy"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Consumers: Internet"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for Business, Energy and Industrial Strategy, pursuant to the Answer of 30 April 2019 to Question 245672 on Consumers: Internet, what steps his Department is taking to ensure that the Consumer Protection from Unfair Trading Regulations 2008 are fully enforced.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255292"}
, {"_about" : "http://data.parliament.uk/resources/1127080", "AnsweringBody" : [{"_value" : "Treasury"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1127080/answer", "answerText" : {"_value" : " Members of the International Civil Aviation Organisation (ICAO), including the United Kingdom, are prevented from taxing international aviation fuel, or any proxies for fuel, under the Chicago Convention. However, Air Passenger Duty \u2013 which raised £3.4 billion in 2017-18 \u2013 ensures that the air travel sector contributes to the cost of public services.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4320", "label" : {"_value" : "Biography information for Robert Jenrick"}
}
, "answeringMemberConstituency" : {"_value" : "Newark"}
, "answeringMemberPrinted" : {"_value" : "Robert Jenrick"}
, "dateOfAnswer" : {"_value" : "2019-05-21", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-21T13:38:20.273Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "14"}
, "answeringDeptShortName" : {"_value" : "Treasury"}
, "answeringDeptSortName" : {"_value" : "Treasury"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Aviation: Fuels"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Chancellor of the Exchequer, what recent assessment he has made of the merits of introducing fuel duty or VAT on aviation fuel.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255293"}
, {"_about" : "http://data.parliament.uk/resources/1127094", "AnsweringBody" : [{"_value" : "Home Office"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1127094/answer", "answerText" : {"_value" : " Tier 4 visa applications are assessed in accordance with the Immigration Rules. Applicants are treated equitably and must meet the same requirements to qualify for leave under a given Tier 4 route and type of sponsor. Nationals of countries listed in Appendix H are subject to reduced documentary requirements although they must meet the same substantive requirements as other nationals. This list is kept under review and we may add or remove countries and competent authorities based on objective criteria. Applicants intending to study at Tier 4 Visa Pilot Scheme institutions are also subject to reduced documentary requirements.<\/p> We will keep the visa application process for international students under review, with the aim of improving the customer journey both for students and their sponsoring institutions. This will include reviewing processes for conducting interviews to ensure that these are appropriately focussed and to minimise any inconvenience for applicants.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4048", "label" : {"_value" : "Biography information for Caroline Nokes"}
}
, "answeringMemberConstituency" : {"_value" : "Romsey and Southampton North"}
, "answeringMemberPrinted" : {"_value" : "Caroline Nokes"}
, "dateOfAnswer" : {"_value" : "2019-05-21", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-21T13:03:59.727Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "1"}
, "answeringDeptShortName" : {"_value" : "Home Office"}
, "answeringDeptSortName" : {"_value" : "Home Office"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Entry Clearances: Overseas Students"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for the Home Department, what steps his Department is taking to ensure that Tier 4 visa applications are treated equitably in respect of (a) country of application and (b) intended place of study.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255294"}
, {"_about" : "http://data.parliament.uk/resources/1127095", "AnsweringBody" : [{"_value" : "Department of Health and Social Care"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1127095/answer", "answerText" : {"_value" : " Each individual medical school sets its own undergraduate medical curriculum. These have to meet the standards set by the General Medical Council (GMC), who then monitor and check to make sure that these standards are maintained.<\/p> The curricula for postgraduate specialty training is set by individual royal colleges and faculties, and the GMC approves curricula and assessment systems for each training programme. Training curricula for doctors emphasise the skills and approaches that a doctor must develop in order to ensure accurate and timely diagnoses and treatment plans for their patients. The Royal College of General Practitioners sets the curriculum for general practitioners (GPs). In order to demonstrate the core competences in the care of children and young people, the curriculum sets out that GPs should be aware of the early presenting symptoms of childhood cancers and possible differentials, such as retinoblastoma.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4455", "label" : {"_value" : "Biography information for Seema Kennedy"}
}
, "answeringMemberConstituency" : {"_value" : "South Ribble"}
, "answeringMemberPrinted" : {"_value" : "Seema Kennedy"}
, "dateOfAnswer" : {"_value" : "2019-05-21", "_datatype" : "dateTime"}
, "groupedQuestionUIN" : {"_value" : "255296"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-21T16:18:23.137Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "17"}
, "answeringDeptShortName" : {"_value" : "Health and Social Care"}
, "answeringDeptSortName" : {"_value" : "Health and Social Care"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Retinoblastoma: Children"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for Health and Social Care, what steps his Department is taking to ensure that GPs are trained to identify retinoblastoma in young children.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255295"}
, {"_about" : "http://data.parliament.uk/resources/1127100", "AnsweringBody" : [{"_value" : "Department of Health and Social Care"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1127100/answer", "answerText" : {"_value" : " Each individual medical school sets its own undergraduate medical curriculum. These have to meet the standards set by the General Medical Council (GMC), who then monitor and check to make sure that these standards are maintained.<\/p> The curricula for postgraduate specialty training is set by individual royal colleges and faculties, and the GMC approves curricula and assessment systems for each training programme. Training curricula for doctors emphasise the skills and approaches that a doctor must develop in order to ensure accurate and timely diagnoses and treatment plans for their patients. The Royal College of General Practitioners sets the curriculum for general practitioners (GPs). In order to demonstrate the core competences in the care of children and young people, the curriculum sets out that GPs should be aware of the early presenting symptoms of childhood cancers and possible differentials, such as retinoblastoma.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4455", "label" : {"_value" : "Biography information for Seema Kennedy"}
}
, "answeringMemberConstituency" : {"_value" : "South Ribble"}
, "answeringMemberPrinted" : {"_value" : "Seema Kennedy"}
, "dateOfAnswer" : {"_value" : "2019-05-21", "_datatype" : "dateTime"}
, "groupedQuestionUIN" : {"_value" : "255295"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-21T16:18:23.197Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "17"}
, "answeringDeptShortName" : {"_value" : "Health and Social Care"}
, "answeringDeptSortName" : {"_value" : "Health and Social Care"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Retinoblastoma: Children"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for Health and Social Care, what steps his Department is taking to ensure that optometrists are trained to identify retinoblastoma at an early stage in young children.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255296"}
, {"_about" : "http://data.parliament.uk/resources/1127226", "AnsweringBody" : [{"_value" : "Department for Education"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1127226/answer", "answerText" : {"_value" : " The Government is committed to an ambitious programme of activity to support good physical and mental health in children and young people. The Department for Education is working closely with the Department for Health and Social Care to provide support for schools so that they can promote good physical and mental wellbeing amongst their pupils.<\/p> <\/p> As part of this, the Government is making the teaching of health education compulsory in all state-funded schools from September 2020. Relationships education will be taught in all primary schools and relationships and sex education in all secondary schools. Schools are being encouraged and supported to start teaching these new subjects from September 2019.<\/p> <\/p> The statutory guidance for the new subjects sets out that pupils should be taught about the similarities and differences between the online world and the physical world. This should cover the impact of unhealthy or obsessive comparison with others online including through setting unrealistic expectations for body image and how people may curate a specific image of their life online.<\/p> The Department is also producing supporting information for schools on how to teach about issues related to internet safety across the curriculum. This will cover information about the types of harms that young people could face online, including the impact that internet content can have on body confidence, along with guidance about teaching children how to assess critically what they encounter online.<\/p> <\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/111", "label" : {"_value" : "Biography information for Nick Gibb"}
}
, "answeringMemberConstituency" : {"_value" : "Bognor Regis and Littlehampton"}
, "answeringMemberPrinted" : {"_value" : "Nick Gibb"}
, "dateOfAnswer" : {"_value" : "2019-05-22", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-22T12:51:27.797Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "60"}
, "answeringDeptShortName" : {"_value" : "Education"}
, "answeringDeptSortName" : {"_value" : "Education"}
, "date" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Pupils: Health"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for Education, what discussions he has had with the Secretary of State for Health and Social Care on (a) creating a body image and media literacy toolkit and (b) making it a compulsory element of the school curriculum.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "255300"}
, {"_about" : "http://data.parliament.uk/resources/1126953", "AnsweringBody" : [{"_value" : "Department for Education"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1126953/answer", "answerText" : {"_value" : " Entitlement to student finance and home fees status in the UK after the implementation period for those outside the scope of the Withdrawal Agreement is under consideration by the UK government and the devolved administrations.<\/p> For EU students already enrolled on courses in the UK, if the UK leaves the EU without a deal, the UK government has already provided certainty. Students from the EU starting courses in England in the 2019/20 academic year will continue to be eligible for \u2018home fee status\u2019, meaning they will be charged the same tuition fees as UK students and have access to tuition fee loans for the duration of their studies.<\/p> More broadly, the UK government has been engaging directly with their EU counterparts on a range of issues, including securing citizens\u2019 rights reassurances. These span a number of areas including on access to education.<\/p> <\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/4021", "label" : {"_value" : "Biography information for Chris Skidmore"}
}
, "answeringMemberConstituency" : {"_value" : "Kingswood"}
, "answeringMemberPrinted" : {"_value" : "Chris Skidmore"}
, "dateOfAnswer" : {"_value" : "2019-05-20", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-20T15:41:11.653Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "60"}
, "answeringDeptShortName" : {"_value" : "Education"}
, "answeringDeptSortName" : {"_value" : "Education"}
, "date" : {"_value" : "2019-05-15", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Higher Education: EU Countries"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Secretary of State for Education, what recent progress his Department has made to ensure reciprocal arrangements on student fees with EU partners after the UK leaves the EU.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "254753"}
, {"_about" : "http://data.parliament.uk/resources/1126029", "AnsweringBody" : [{"_value" : "Treasury"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1126029/answer", "answerText" : {"_value" : " The sale of food that is formulated and held out for sale exclusively for working dogs, which includes assistance and therapy dogs, is zero rated. The VAT rules in this area are long-standing and have not changed.<\/p>"}
, "answeringMember" : {"_about" : "http://data.parliament.uk/members/3935", "label" : {"_value" : "Biography information for Mel Stride"}
}
, "answeringMemberConstituency" : {"_value" : "Central Devon"}
, "answeringMemberPrinted" : {"_value" : "Mel Stride"}
, "dateOfAnswer" : {"_value" : "2019-05-16", "_datatype" : "dateTime"}
, "isMinisterialCorrection" : {"_value" : "false", "_datatype" : "boolean"}
, "questionFirstAnswered" : [{"_value" : "2019-05-16T13:30:33.173Z", "_datatype" : "dateTime"}
]}
, "answeringDeptId" : {"_value" : "14"}
, "answeringDeptShortName" : {"_value" : "Treasury"}
, "answeringDeptSortName" : {"_value" : "Treasury"}
, "date" : {"_value" : "2019-05-13", "_datatype" : "dateTime"}
, "hansardHeading" : {"_value" : "Assistance Animals: Food"}
, "houseId" : {"_value" : "1"}
, "legislature" : [{"_about" : "http://data.parliament.uk/terms/25259", "prefLabel" : {"_value" : "House of Commons"}
}
], "questionText" : "To ask the Chancellor of the Exchequer, for what reasons VAT will be charged on food for assistance and therapy dogs.", "registeredInterest" : {"_value" : "false", "_datatype" : "boolean"}
, "tablingMember" : {"_about" : "http://data.parliament.uk/members/1436", "label" : {"_value" : "Biography information for Paul Farrelly"}
}
, "tablingMemberConstituency" : {"_value" : "Newcastle-under-Lyme"}
, "tablingMemberPrinted" : [{"_value" : "Paul Farrelly"}
], "uin" : "253520"}
, {"_about" : "http://data.parliament.uk/resources/1126030", "AnsweringBody" : [{"_value" : "Department of Health and Social Care"}
], "answer" : {"_about" : "http://data.parliament.uk/resources/1126030/answer", "answerText" : {"_value" : " Public Health England (PHE) ensures health professionals have current, accurate information on the benefits of immunisation, so they can communicate this information to parents. PHE provides the Department with expert evidence and advice (and nationally procures many vaccines). PHE also supports NHS England with information, expert advice, capacity and support at national and local level.<\/p> PHE recommends people visit the National Health Service website as the NHS is a highly trusted source of information. This is available at the following link:<\/p>