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<p>At its meeting in February 2014, the Pharmacovigilance Risk Assessment Committee
(PRAC) of the European Medicines Agency recommended that the product information for
mefloquine (Lariam) be amended to state that neuropsychiatric adverse reactions may
persist for months, or longer, even after discontinuation of the drug. The Medicines
and Healthcare products Regulatory Agency (MHRA) accepted the recommendations and
implemented the advice of the PRAC, which is reflected in the United Kingdom product
information for mefloquine. In addition, the MHRA has since taken further action to
ensure that these risks are adequately conveyed to UK prescribers and patients in
the form of improved checklists for healthcare professionals and a patient alert card.</p>
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