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1129140

	registered interest
	date	03/06/2019
	answering body	Home Office
	answering dept id	1
	answering dept short name	Home Office
	answering dept sort name	Home Office
	hansard heading	Police: Pensions
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for the Home Department, what steps he is taking to ensure that widows of deceased police officers are not discriminated against upon remarrying in relation to their entitlement to a survivor’s pension.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	259292
	answer	answer is ministerial correction date of answer 10/06/2019 answer text <p>Survivors of officers who were members of the 2006 and 2015 police pension schemes are, since 2006, paid survivor pensions for life.</p><p>On 18 January 2016, the Police Pensions Regulations 1987 and the Police (Injury Benefit) Regulations 2006 were amended to allow widows, widowers and civil partners of police officers in England and Wales who have died on duty and who qualified for a survivor pension after 1 April 2015 to continue to receive their survivors’ benefits for life. Successive governments have been clear that there is a general presumption against making retrospective changes to public service pension schemes. However, the Government believes the arguments for making a limited exception for the widows of police officers who died on duty are sufficiently compelling in this case.</p> answering member constituency Ruislip, Northwood and Pinner answering member printed Mr Nick Hurd question first answered 10/06/2019 15:25:00 answering member 1561 label Biography information for Mr Nick Hurd
	tabling member	4447 label Biography information for Maggie Throup

1608728

	registered interest
	date	29/03/2023
	answering body	Foreign, Commonwealth and Development Office
	answering dept id	208
	answering dept short name	Foreign, Commonwealth and Development Office
	answering dept sort name	Foreign, Commonwealth and Development Office
	hansard heading	Developing Countries: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Foreign, Commonwealth and Development Affairs, what steps his Department is taking to support the increase in bacterial vaccine manufacturing capacity in Low to Middle Income Countries.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	176686
	answer	answer is ministerial correction date of answer 17/04/2023 answer text <p>The UK supports the expansion of vaccine manufacturing in low- and middle-income countries and is working with international and regional partners (including Gavi, the Coalition for Epidemic Preparedness Innovations (CEPI) and the Partnership for African Vaccine Manufacturing (PAVM)), development banks and the private sector to catalyse strategic investments for vaccine manufacturing in these countries. The UK is the second largest funder of Gavi, who are developing a strategy to support regional manufacturing capacity in low- and middle-income countries. The strategy aims to address barriers to investment in regional manufacturing and support efficient market outcomes.</p> answering member constituency Sutton Coldfield answering member printed Mr Andrew Mitchell question first answered 17/04/2023 15:47:26 answering member 1211 label Biography information for Mr Andrew Mitchell
	tabling member	4447 label Biography information for Maggie Throup

1675224

	registered interest
	date	04/12/2023
	answering body	Foreign, Commonwealth and Development Office
	answering dept id	208
	answering dept short name	Foreign, Commonwealth and Development Office
	answering dept sort name	Foreign, Commonwealth and Development Office
	hansard heading	Development Aid: Health Services
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Minister of State, Foreign, Commonwealth and Development Office, whether his Department plans to (a) maintain and (b) increase funding for Product Development Partnerships.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	5087
	answer	answer is ministerial correction date of answer 11/12/2023 answer text <p>The Foreign Commonwealth and Development Office (FCDO) remains committed to investing in Product Development Partnerships and other global health Research and Development organisations. We plan to launch a call for proposals for funding the development of products and technologies to combat diseases of poverty, for use in Low and Lower Middle Income Countries.</p><p>At this stage, FCDO plans to invest approximately £230 million in new funding for product development research for health over a 3 - 4 year period from 2023/24.</p> answering member constituency Sutton Coldfield answering member printed Mr Andrew Mitchell question first answered 11/12/2023 13:49:21 answering member 1211 label Biography information for Mr Andrew Mitchell
	tabling member	4447 label Biography information for Maggie Throup

1675225

	registered interest
	date	04/12/2023
	answering body	Foreign, Commonwealth and Development Office
	answering dept id	208
	answering dept short name	Foreign, Commonwealth and Development Office
	answering dept sort name	Foreign, Commonwealth and Development Office
	hansard heading	Vaccination: Research
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Minister of State, Foreign, Commonwealth and Development Office, what funding his Department provided for vaccine research and development in each of the last five years; and what he plans to provide in each of the next five years.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	5088
	answer	answer is ministerial correction date of answer 11/12/2023 answer text <p>Over the last 5 financial years (2018/19 to 2022/23) the Foreign, Commonwealth and Development Office (FCDO) have invested the following amounts in research and development for vaccines to combat diseases of poverty for use in low and lower middle-income countries:</p><table><tbody><tr><td><p>2018/19</p></td><td><p>2019/20</p></td><td><p>2020/21</p></td><td><p>2021/22</p></td><td><p>2022/23</p></td></tr><tr><td><p>£8,528,752</p></td><td><p>£29,589,803</p></td><td><p>£213,773,395</p></td><td><p>£2,391,511</p></td><td><p>£13,012,567</p></td></tr></tbody></table><p>To date, FCDO has entered into agreements to invest the following amounts on vaccine Research and Development over the next 5 financial years (2023/24 to 2027/28)*:</p><table><tbody><tr><td><p>2023/24</p></td><td><p>2024/25</p></td><td><p>2025/26</p></td><td><p>2026/27</p></td><td><p>2027/28</p></td></tr><tr><td><p>£17,008,587</p></td><td><p>£18,626,489</p></td><td><p>£17,253,808</p></td><td><p>£17,000,000</p></td><td><p>£0</p></td></tr></tbody></table><p>* The overall investment in vaccine development could increase as a result of a planned funding competition for the research and development of health products to combat diseases of poverty.</p> answering member constituency Sutton Coldfield answering member printed Mr Andrew Mitchell question first answered 11/12/2023 15:10:46 answering member 1211 label Biography information for Mr Andrew Mitchell
	tabling member	4447 label Biography information for Maggie Throup

1565654

	registered interest
	date	10/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Influenza: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, what percentage by cohort of (a) children aged 2 and 3 years on 31 August 2022, (b) school-aged children including all primary school aged children and eligible secondary school aged children, (c) people aged 6 months to under 50 years in clinical risk groups, (d) pregnant women, (e) people aged 50 to 64, (f) people aged 65 to 74, (g) people aged 75 and over, (h) people staying in long-stay residential care homes, (i) people who are carers, (j) people in receipt of carer’s allowance, (k) the main carer of an older or disabled person, (m) people who are in close contact with immunocompromised individuals and (n) frontline health and social care workers who had taken up the offer of a free seasonal flu vaccination by (A) 30 November 2022 and (B) 31 December 2022.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	120089
	answer	answer is ministerial correction date of answer 16/01/2023 answer text <p>The information requested is not held centrally. However, the United Kingdom Health Security Agency (UKHSA) publish seasonal influenza vaccine uptake in general practitioner patients. The following table shows the provisional monthly data for 1 September 2022 to 30 November 2022 for various cohorts and seasonal influenza vaccine uptake provisional data for all school aged primary school children in England given from the 1 September 2022 to the 30 November 2022.</p><table><tbody><tr><td><p>Cohort</p></td><td><p>Uptake 30 November 2022 (%)</p></td></tr><tr><td><p>65 years old and over</p></td><td><p>76.2</p></td></tr><tr><td><p>6 months old to under 65 years old at-risk</p></td><td><p>42.7</p></td></tr><tr><td><p>Pregnant women</p></td><td><p>30.0</p></td></tr><tr><td><p>50 years old to under 65 years old and not in a clinical risk group</p></td><td><p>35.6</p></td></tr><tr><td><p>50 years old to 65 years old and in a clinical risk group</p></td><td><p>56.7</p></td></tr><tr><td><p>All 2 year olds (combined)</p></td><td><p>34.5</p></td></tr><tr><td><p>All 3 year olds (combined)</p></td><td><p>36.7</p></td></tr><tr><td><p>Reception (age 4 years old to 5 years old)</p></td><td><p>47.8</p></td></tr><tr><td><p>Year 1 (age 5 years old to 6 years old)</p></td><td><p>48.3</p></td></tr><tr><td><p>Year 2 (age 6 years old to 7 years old)</p></td><td><p>49.3</p></td></tr><tr><td><p>Year 3 (age 7 years old to 8 years old)</p></td><td><p>48.9</p></td></tr><tr><td><p>Year 4 (age 8-9 years old)</p></td><td><p>48.2</p></td></tr><tr><td><p>Year 5 (age 9-10 years old)</p></td><td><p>47.5</p></td></tr><tr><td><p>Year 6 (age 10-11 years old)</p></td><td><p>46.0</p></td></tr><tr><td><p>All primary school age (age 4 years old to 11 years old)</p></td><td><p>48.0</p></td></tr></tbody></table><p>Source: Seasonal influenza vaccine uptake in GP patients: monthly data, 2022 to 2023 and Seasonal influenza vaccine uptake in children of school age: monthly data, 2022 to 2023, UKHSA</p><p>Data for December 2022 will be published at the end of January 2023 and data for secondary school aged children will be published on 26 January 2023.</p><p>UKHSA has published provisional data for Seasonal influenza uptake amongst frontline healthcare workers (HCWs) in England 2022 to 2023 for the period 1 September 2022 to 30 November 2022, it is 41.8%. The data for December 2022 will be published at the end of January 2023.</p><p>As of the week, ending 18 December 2022, the proportions who had received their flu vaccination for the 2022 to 2023 season were, 70.1% of total residents and 13.8% of total staff of older adult care homes:</p><p>Vaccine uptake for carers will be published in the 2022 to 2023 annual report</p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 16/01/2023 17:33:02 answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup

1565655

	registered interest
	date	10/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Coronavirus: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, what percentage by cohort of (a) people aged 50 to 64, (b) people aged 65 to 74, (c) people aged 75 and over, (d) pregnant women, (e) people aged 5 and over and at high risk from covid-19 due to a health condition or a weakened immune system, (f) people aged 5 and over who live with someone who has a weakened immune system, (g) people aged 16 and over and who are carers, either paid or unpaid, (h) people living or working in a care home for older people and (i) frontline health and social care workers who had taken up the offer of a free covid-19 booster vaccination by (A) 30 November 2022 and (B) 31 December 2022.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	120090
	answer	answer is ministerial correction date of answer 13/01/2023 answer text <p>The information requested is not held. However, the following table shows the booster uptake in age group from 50 years old to 90 years old and over by 30 November 2022 and 31 December 2022.</p><table><tbody><tr><td>Age Group</td><td>Booster uptake 30 November 2022 (%)</td><td>Booster uptake 31 December 2022 (%)</td></tr><tr><td><p>50-54</p><p>years</p><p>old</p></td><td>38.3</td><td>41.8</td></tr><tr><td><p>55-59</p><p>years</p><p>old</p></td><td>48.5</td><td>51.5</td></tr><tr><td><p>60-64</p><p>years</p><p>old</p></td><td>58.1</td><td>60.8</td></tr><tr><td><p>65-69</p><p>years</p><p>old</p></td><td>70.1</td><td>71.6</td></tr><tr><td><p>70-74</p><p>years</p><p>old</p></td><td>77.5</td><td>78.7</td></tr><tr><td><p>75-79 years old</p></td><td>80.8</td><td>82.1</td></tr><tr><td><p>80-84</p><p>years</p><p>old</p></td><td>81.2</td><td>82.5</td></tr><tr><td><p>85-89</p><p>years</p><p>old</p></td><td>80.7</td><td>82.2</td></tr><tr><td><p>90+</p><p>years</p><p>old</p></td><td>77.9</td><td>79.9</td></tr></tbody></table><p>Source: <a href="https://coronavirus.data.gov.uk/details/vaccinations?areaType=nation&amp;areaName=England" target="_blank">https://coronavirus.data.gov.uk/details/vaccinations?areaType=nation&amp;areaName=England</a></p><p>Data on vaccine uptake in pregnant women is published by the UK Health Security Agency (UKHSA) in the Vaccine Surveillance Report, data is available up to June 2022. Of women who gave birth in June 2022, 67.3%, 24,933 of 37,037, had received 2 doses of the vaccine before they gave birth.</p><p>The National Health Service publishes data on the total number of people who have had an Autumn Booster dose to date, 12 January for Health Care Workers, immunosuppressed and those at risk in the age bracket, of five years old to 49 years old. Individuals identified as carers in their general practitioner record were included in this cohort but from 1 December 2022 carers are no longer included.</p><p>UKHSA publish monthly reports on seasonal influenza and COVID-19 vaccine uptake in frontline healthcare workers. Data published to the end of November 2022 showed that in 165 NHS Trusts providing a return, 338,602 frontline healthcare workers had received a COVID vaccine since 1 September 2022, an uptake of 36.3 %.</p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 13/01/2023 17:06:12 answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup

1565656

	registered interest
	date	10/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Coronavirus and Influenza: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, what steps his Department is taking to promote the uptake of free (a) seasonal flu and (b) COVID-19 booster vaccinations to eligible cohorts in winter 2022/23..
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	120091
	answer	answer is ministerial correction date of answer 18/01/2023 answer text <p>The Department together with the National Health Service and UK Health Security Agency are providing advice and information to support those getting the COVID-19 and flu vaccines and to anyone who might have questions about the vaccination process.</p><p> </p><p>Our communications include information and advice shared via television, radio and social media. This has been translated into 28 languages including Albanian, Arabic, Brazilian, Chinese, Hindi, Polish, Tagalog and Urdu. A new country-wide marketing campaign urging millions of eligible people to get their flu and COVID-19 booster vaccines to top up their immunity was launched on 24 October 2022. This includes targeted communications for ethnic minority communities, with a particular focus on those with low vaccine confidence.</p><p> </p><p>Multicultural community activity is seeing teams of campaign ambassadors engage with a range of different ethnic groups who tend to be more vaccine hesitant. This is taking place across the country in high footfall places of worship and nearby community settings.</p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 18/01/2023 12:20:07 answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup

1565657

	registered interest
	date	10/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Coronavirus and Influenza: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, how much his Department plans to spend on promoting the uptake of free (a) seasonal flu and (b) covid-19 booster vaccinations to eligible cohorts in winter 2022-23; and how much was spent on promoting those vaccinations in winter 2021-22.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	120092
	answer	answer is ministerial correction date of answer 16/01/2023 answer text <p>The 2022/23 campaign to promote uptake of seasonal flu and COVID-19 booster vaccinations had a media spend of £3.02 million. This was an integrated winter vaccinations campaign therefore it is not possible to split out the spend by vaccine. The 2021/22 campaign to promote uptake of seasonal flu and COVID-19 booster vaccinations had a media spend of £11.5 million. This was also an integrated winter vaccinations campaign and spend cannot be separated out by vaccine.</p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 16/01/2023 17:34:37 answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup

1568078

	registered interest
	date	18/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Influenza: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, if he will make an estimate of the number and proportion of (a) children aged two and three years on 31 August 2022, (b) primary school-aged children and eligible secondary school-aged children, (c) people aged six months to 50 years in clinical risk groups, (d) pregnant women, (e) people aged 50 to 64, (f) people aged 65 to 74, (g) people aged 75 and over, (h) people staying in long-stay residential care homes, (i) people who are carers, (j) people in receipt of carer’s allowance, (k) the main carer of an older or disabled person, (m) people who are in close contact with immunocompromised individuals and (n) frontline health and social care workers who had taken up a free seasonal flu vaccination by (i) 30 November 2021 and (ii) 31 December 2021.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	126701
	answer	answer is ministerial correction date of answer 03/02/2023 answer text <p>We do not have all the information in the format requested.</p><p>Please see the attachment for the information provided.</p><p>Flu vaccine uptake is published at the following links:</p><p><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.uk%2Fgovernment%2Fstatistics%2Fseasonal-flu-vaccine-uptake-in-gp-patients-monthly-data-2021-to-2022&amp;data=05%7C01%7CParliamentary1%40ukhsa.gov.uk%7Ca49287e1a6b34700eafa08db02a74770%7Cee4e14994a354b2ead475f3cf9de8666%7C0%7C0%7C638106690009332763%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=7rom1ziGM2TWayVbhS8jsgebBXN4JetxGsxE1OcuKy0%3D&amp;reserved=0" target="_blank">https://www.gov.uk/government/statistics/seasonal-flu-vaccine-uptake-in-gp-patients-monthly-data-2021-to-2022</a></p><p><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.uk%2Fgovernment%2Fstatistics%2Fseasonal-flu-vaccine-uptake-in-children-of-school-age-monthly-data-2021-to-2022&amp;data=05%7C01%7CParliamentary1%40ukhsa.gov.uk%7Ca49287e1a6b34700eafa08db02a74770%7Cee4e14994a354b2ead475f3cf9de8666%7C0%7C0%7C638106690009332763%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=2GZHsZFnRBMV745moKYw3naih%2B4r7DXpuPUOJcq%2F%2FJ8%3D&amp;reserved=0" target="_blank">https://www.gov.uk/government/statistics/seasonal-flu-vaccine-uptake-in-children-of-school-age-monthly-data-2021-to-2022</a><br></p><p><a href="https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.uk%2Fgovernment%2Fstatistics%2Fseasonal-flu-and-covid-19-vaccine-uptake-in-frontline-healthcare-workers-monthly-data-2021-to-2022&amp;data=05%7C01%7CParliamentary1%40ukhsa.gov.uk%7Ca49287e1a6b34700eafa08db02a74770%7Cee4e14994a354b2ead475f3cf9de8666%7C0%7C0%7C638106690009332763%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=Ll%2FJ42ADYZiYgNrar7iqwRq%2FKnpTtOf4UO2E6z5y8Fw%3D&amp;reserved=0" target="_blank">https://www.gov.uk/government/statistics/seasonal-flu-and-covid-19-vaccine-uptake-in-frontline-healthcare-workers-monthly-data-2021-to-2022</a></p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 03/02/2023 10:48:22 answering member 4492 label Biography information for Maria Caulfield attachment 1 file name Number and proportion taking up flu vaccine.docx title Number and proportion taking up free flu vaccine previous answer version 49400 answering member constituency Lewes answering member printed Maria Caulfield answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup

1568079

	registered interest
	date	18/01/2023
	answering body	Department of Health and Social Care
	answering dept id	17
	answering dept short name	Health and Social Care
	answering dept sort name	Health and Social Care
	hansard heading	Coronavirus: Vaccination
	house id	1
	legislature	25259 pref label House of Commons
	question text	To ask the Secretary of State for Health and Social Care, if he will make an estimate of the number and proportion of (a) people aged 50 to 64, (b) people aged 65 to 74, (c) people aged 75 and over, (d) pregnant women, (e) people aged five and over at high risk from covid-19 due to a health condition or weakened immune system, (f) people aged five and over who live with someone who has a weakened immune system, (g) people aged 16 and over who are paid or unpaid carers, (h) people living or working in a care home for older people and (i) frontline health and social care workers who had taken up a free covid-19 booster vaccination by (i) 30 November 2021 and (ii) 31 December 2021.
	tabling member constituency	Erewash
	tabling member printed	Maggie Throup
	uin	126702
	answer	answer is ministerial correction date of answer 03/02/2023 answer text <p>We do not have all the information in the format requested.</p><p>Please see the attachment for the information provided.</p><p>This information is published at the following links:</p><p><a href="https://www.gov.uk/government/statistics/national-flu-and-covid-19-surveillance-reports-2021-to-2022-season" target="_blank">https://www.gov.uk/government/statistics/national-flu-and-covid-19-surveillance-reports-2021-to-2022-season</a></p><p><a href="https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-vaccinations/covid-19-vaccinations-archive/" target="_blank">https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-vaccinations/covid-19-vaccinations-archive/</a></p><p><a href="https://www.gov.uk/government/statistics/seasonal-flu-and-covid-19-vaccine-uptake-in-frontline-healthcare-workers-monthly-data-2021-to-2022" target="_blank">https://www.gov.uk/government/statistics/seasonal-flu-and-covid-19-vaccine-uptake-in-frontline-healthcare-workers-monthly-data-2021-to-2022</a></p> answering member constituency Lewes answering member printed Maria Caulfield question first answered 03/02/2023 10:54:44 answering member 4492 label Biography information for Maria Caulfield attachment 1 file name Number and proportion taking up covid-19 booster.docx title Number and proportion taking up COVID-19 booster previous answer version 49402 answering member constituency Lewes answering member printed Maria Caulfield answering member 4492 label Biography information for Maria Caulfield
	tabling member	4447 label Biography information for Maggie Throup