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date	2015-01-22
min answer › date of answer	2015-02-05
min date tabled	2015-01-13
max date tabled	2019-06-10
max ddp modified	2015-02-08T21:22:53.127Z
title	House of Lords Tabled Parliamentary Question 2014%2F15 HL4366

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175363

registered interest

date

22/01/2015

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Department of Health

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Health

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Health

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IVF

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25277

pref label	House of Lords

question text

To ask Her Majesty’s Government, further to the Written Answer by Earl Howe on 6 January (HL3839), whether they can provide any extant examples of a "gene therapy" that does not modify any genes, of a "germ line therapy" that does not affect the germ line, or of a "germ line gene therapy" that does not affect any genes to be transmitted through the germ line; if not, what is the basis of their assertion that a "germ line gene therapy" does not constitute genetic modification; how discussion is clarified by defining genetic modification such that it "is not that that is what it is"; and whether they will place in the Library of the House copies of any written contributions towards the development of the working definition by the Department for Business, Innovation and Skills, the Wellcome Trust and the Nuffield Council on Bioethics.

tabling member printed

Lord Alton of Liverpool

uin

HL4366

answer

is ministerial correction

date of answer

05/02/2015

answer text

The working definition adopted by the Government for the purpose of taking forward the Mitochondrial Donation regulations states that genetic modification involves the germ-line modification of nuclear DNA (in the chromosomes) that can be passed on to future generations. Mitochondrial donation is not considered to be genetic modification, as the patient’s nuclear DNA remains unaltered during this process. However, the Nuffield Council on Bioethics considered that it can be defined as germ line therapy because the techniques “introduce a change that is incorporated into the (mitochondrial) genes of the resulting people, and so will be incorporated into the germline that they will go on to develop”. Furthermore, because mitochondria are inherited down the maternal line “only women born from these techniques would be able to pass the changes on to their children” and this form of germ line gene therapy does not affect any genes transmitted through the germ line of men born through these techniques. Cancer gene therapy intended to activate an anti-tumour immune response is an example of gene therapy that does not modify any genes. The working definition of genetic modification in humans is intended to assist in taking forward the debate on mitochondrial donation.

answering member printed

Earl Howe

question first answered

05/02/2015 16:47:13

answering member

2000

label	Biography information for Earl Howe

tabling member

738

label	Biography information for Lord Alton of Liverpool