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780496

registered interest
date	30/10/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Human Papillomavirus: Vaccination
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, how many Yellow Cards submitted to the Medicines and Healthcare Products Regulatory Agency on the HPV vaccination have been classified as serious in the last three years.
tabling member constituency	Mansfield
tabling member printed	Ben Bradley
uin	110248
answer	answer is ministerial correction date of answer 07/11/2017 answer text <p>The Medicines and Healthcare products Regulatory Agency (MHRA) encourages anyone to report a suspected adverse reaction (ADR) to a vaccine or medicine through the Yellow Card Scheme:</p><p> </p><p><a href="http://www.mhra.gov.uk/yellowcard" target="_blank">www.mhra.gov.uk/yellowcard</a></p><p>A Yellow Card report is not proof of a side effect occurring, but a suspicion by the reporter that the vaccine or medicine may have been the cause. Such reports are kept under continual review to identify potential new risks.</p><p> </p><p>Between 31 October 2014 – 30 October 2017 a total of 649 serious suspected adverse reaction (ADR) reports with human papilloma virus (HPV) vaccines have been reported to the Medicines and Healthcare products Regulatory Agency (MHRA) via the Yellow Card Scheme (data run date: 1 November 2017). In this three year period, at least 1 million doses of HPV vaccine were administered in the United Kingdom.</p><p> </p><p>A breakdown of UK serious suspected spontaneous ADR reports received via the Yellow Card Scheme beween 31 October 2014 – 30 October 2016 by brand and year received is shown in the following table.</p><p> </p><table><tbody><tr><td><p>HPV Vaccine</p></td><td><p>Number of serious reports</p></td></tr><tr><td><p>HPV brand unspecified</p></td><td><p>181</p></td></tr><tr><td><p>Cervarix</p></td><td><p>64</p></td></tr><tr><td><p>Gardasil</p></td><td><p>390</p></td></tr><tr><td><p>Gardasil 9</p></td><td><p>18</p></td></tr><tr><td><p>Total</p></td><td><p>649</p></td></tr></tbody></table><p> </p><p>Source: MHRA sentinel database for adverse reactions</p><p> </p><p>Notes:</p><p> </p><p>The total number of reports received by vaccine brand is not equal to the totals in the table above as some reports included more than one HPV vaccine brand.</p><p> </p><p>The MHRA has received a total of 3,159 serious suspected adverse reaction reports associated with HPV vaccine (data run date 1 November 2017).</p><p> </p><p>All serious reports received via the Yellow Card Scheme are reviewed based on the details received from the reporter. Follow up letters may be sent for missing information such as vaccine brand name, batch number, medical history, results of investigations, diagnoses and details of outcome.</p><p> </p><p>The Commission on Human Medicines has thoroughly reviewed the safety of HPV vaccines and concluded that the evidence does not support a link between HPV vaccination and the development of chronic illnesses.</p> answering member constituency Winchester answering member printed Steve Brine grouped question UIN 110360 question first answered 07/11/2017 11:31:40 answering member 4067 label Biography information for Steve Brine
tabling member	4663 label Biography information for Ben Bradley

776265

registered interest
date	23/10/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Accident and Emergency Departments: Ear, Nose and Throat Conditions
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, how many patients were admitted via accident and emergency departments with a primary diagnosis of an ENT condition in each month of (a) 2010-11, (b) 2011-12, (c) 2012-13, (d) 2013-14, (e) 2014-15, (f) 2015-16 and (g) 2016-17.
tabling member constituency	Mansfield
tabling member printed	Ben Bradley
uin	108948
answer	answer is ministerial correction date of answer 31/10/2017 answer text <p>A count of unplanned accident and emergency (A&amp;E) attendances<sup>1</sup> resulting in an admission<sup>2</sup> and a primary diagnosis of ear, nose and throat (ENT) conditions<sup>3</sup>, for the financial years between 2010-11 and 2016-17<sup>4</sup> is in the table below.</p><p> </p><p>This is a count of hospital attendances resulting in admissions, not individual patients as the same person may have been admitted into a National Health Service hospital on more than one occasion.</p><p> </p><table><tbody><tr><td><p> </p></td><td><p>2010-11</p></td><td><p>2011-12</p></td><td><p>2012-13</p></td><td><p>2013-14</p></td><td><p>2014-15</p></td><td><p>2015-16</p></td><td><p>2016-17</p></td></tr><tr><td><p>April</p></td><td><p>2,145</p></td><td><p>2,318</p></td><td><p>2,488</p></td><td><p>2,707</p></td><td><p>3,019</p></td><td><p>2,943</p></td><td><p>3,287</p></td></tr><tr><td><p>May</p></td><td><p>2,086</p></td><td><p>2,194</p></td><td><p>2,631</p></td><td><p>2,554</p></td><td><p>2,833</p></td><td><p>2,801</p></td><td><p>3,531</p></td></tr><tr><td><p>June</p></td><td><p>1,999</p></td><td><p>2,163</p></td><td><p>2,402</p></td><td><p>2,407</p></td><td><p>2,640</p></td><td><p>2,840</p></td><td><p>3,128</p></td></tr><tr><td><p>July</p></td><td><p>1,938</p></td><td><p>2,163</p></td><td><p>2,442</p></td><td><p>2,422</p></td><td><p>2,608</p></td><td><p>2,901</p></td><td><p>3,177</p></td></tr><tr><td><p>August</p></td><td><p>1,765</p></td><td><p>2,104</p></td><td><p>2,167</p></td><td><p>2,175</p></td><td><p>2,342</p></td><td><p>2,517</p></td><td><p>2,825</p></td></tr><tr><td><p>September</p></td><td><p>1,791</p></td><td><p>1,942</p></td><td><p>2,203</p></td><td><p>2,104</p></td><td><p>2,207</p></td><td><p>2,560</p></td><td><p>2,719</p></td></tr><tr><td><p>October</p></td><td><p>1,889</p></td><td><p>2,280</p></td><td><p>2,518</p></td><td><p>2,550</p></td><td><p>2,639</p></td><td><p>2,897</p></td><td><p>2,952</p></td></tr><tr><td><p>November</p></td><td><p>1,804</p></td><td><p>2,250</p></td><td><p>2,573</p></td><td><p>2,594</p></td><td><p>2,514</p></td><td><p>3,014</p></td><td><p>3,017</p></td></tr><tr><td><p>December</p></td><td><p>2,134</p></td><td><p>2,431</p></td><td><p>2,894</p></td><td><p>2,748</p></td><td><p>2,829</p></td><td><p>3,111</p></td><td><p>3,196</p></td></tr><tr><td><p>January</p></td><td><p>2,037</p></td><td><p>2,460</p></td><td><p>2,588</p></td><td><p>2,845</p></td><td><p>2,568</p></td><td><p>3,266</p></td><td><p>3,049</p></td></tr><tr><td><p>February</p></td><td><p>1,968</p></td><td><p>2,437</p></td><td><p>2,560</p></td><td><p>2,831</p></td><td><p>2,459</p></td><td><p>3,318</p></td><td><p>3,133</p></td></tr><tr><td><p>March</p></td><td><p>2,301</p></td><td><p>2,624</p></td><td><p>2,931</p></td><td><p>3,014</p></td><td><p>2,822</p></td><td><p>3,696</p></td><td><p>3,492</p></td></tr></tbody></table><p> </p><p>Source: Hospital Episode Statistics (HES), NHS Digital</p><p> </p><p>Notes:</p><p> </p><p><sup>1</sup>The following attendance category codes identify unplanned A&amp;E attendance</p><p>1 = First A&amp;E attendance</p><p>3 = Follow-up A&amp;E attendance – unplanned</p><p>9 = Not known</p><p><sup>2</sup>Attendance disposal 01 = Admitted to hospital bed / become a lodged patient of the same health care provider.</p><p><sup>3</sup>A&amp;E Diagnosis - The recording of the diagnosis field within the A&amp;E data set is not mandatory. It is not known to what extent changes over time are as a result of improvements in recording practice.</p><p>34 = ENT conditions</p><p><sup>4</sup>HES figures are available from 2007-08 onwards. Changes to the figures over time need to be interpreted in the context of improvements in data quality and coverage and changes in NHS practice. For example, changes in activity may be due to changes in the provision of care. Note that HES include activity ending in the year in question and run from April to March, e.g. 2012-13 includes activity occurring between 1 April 2012 and 31 March 2013.</p><p> </p> answering member constituency Ludlow answering member printed Mr Philip Dunne question first answered 31/10/2017 12:01:07 answering member 1542 label Biography information for Philip Dunne
tabling member	4663 label Biography information for Ben Bradley

776266

registered interest
date	23/10/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Accident and Emergency Departments
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, how many patients were admitted via accident and emergency departments with a primary diagnosis of a head injury in each month of (a) 2010-11, (b) 2011-12, (c) 2012-13, (d) 2013-14, (e) 2014-15, (f) 2015-16 and (g) 2016-17.
tabling member constituency	Mansfield
tabling member printed	Ben Bradley
uin	108949
answer	answer is ministerial correction date of answer 31/10/2017 answer text <p>A count of unplanned accident and emergency (A&amp;E) attendances<sup>1</sup> resulting in an admission<sup>2</sup> and a primary diagnosis of head injury<sup>3</sup>, for the financial years between 2010-11 and 2016-17<sup>4</sup> is in the table below.</p><p> </p><p>This is a count of hospital attendances resulting in admissions, not individual patients as the same person may have been admitted into a National Health Service hospital on more than one occasion.</p><p> </p><table><tbody><tr><td><p> </p></td><td><p>2010-11</p></td><td><p>2011-12</p></td><td><p>2012-13</p></td><td><p>2013-14</p></td><td><p>2014-15</p></td><td><p>2015-16</p></td><td><p>2016-17</p></td></tr><tr><td><p>April</p></td><td><p>3,490</p></td><td><p>3,580</p></td><td><p>3,466</p></td><td><p>3,350</p></td><td><p>3,531</p></td><td><p>3,701</p></td><td><p>3,639</p></td></tr><tr><td><p>May</p></td><td><p>3,696</p></td><td><p>3,816</p></td><td><p>3,896</p></td><td><p>3,575</p></td><td><p>3,780</p></td><td><p>3,840</p></td><td><p>4,023</p></td></tr><tr><td><p>June</p></td><td><p>3,284</p></td><td><p>3,617</p></td><td><p>3,522</p></td><td><p>3,636</p></td><td><p>3,884</p></td><td><p>3,972</p></td><td><p>3,762</p></td></tr><tr><td><p>July</p></td><td><p>3,488</p></td><td><p>3,947</p></td><td><p>3,723</p></td><td><p>3,837</p></td><td><p>4,026</p></td><td><p>4,186</p></td><td><p>3,945</p></td></tr><tr><td><p>August</p></td><td><p>3,447</p></td><td><p>3,782</p></td><td><p>3,858</p></td><td><p>3,884</p></td><td><p>3,897</p></td><td><p>3,997</p></td><td><p>4,233</p></td></tr><tr><td><p>September</p></td><td><p>3,521</p></td><td><p>3,851</p></td><td><p>3,837</p></td><td><p>3,697</p></td><td><p>3,851</p></td><td><p>4,102</p></td><td><p>3,978</p></td></tr><tr><td><p>October</p></td><td><p>3,351</p></td><td><p>3,927</p></td><td><p>3,743</p></td><td><p>3,609</p></td><td><p>3,750</p></td><td><p>4,073</p></td><td><p>4,107</p></td></tr><tr><td><p>November</p></td><td><p>3,016</p></td><td><p>3,761</p></td><td><p>3,389</p></td><td><p>3,740</p></td><td><p>3,603</p></td><td><p>3,634</p></td><td><p>3,623</p></td></tr><tr><td><p>December</p></td><td><p>2,815</p></td><td><p>3,912</p></td><td><p>3,344</p></td><td><p>3,719</p></td><td><p>3,379</p></td><td><p>3,494</p></td><td><p>3,720</p></td></tr><tr><td><p>January</p></td><td><p>3,023</p></td><td><p>3,379</p></td><td><p>3,186</p></td><td><p>3,589</p></td><td><p>3,221</p></td><td><p>3,482</p></td><td><p>3,293</p></td></tr><tr><td><p>February</p></td><td><p>2,925</p></td><td><p>3,166</p></td><td><p>2,981</p></td><td><p>3,397</p></td><td><p>2,932</p></td><td><p>3,150</p></td><td><p>3,158</p></td></tr><tr><td><p>March</p></td><td><p>3,303</p></td><td><p>3,679</p></td><td><p>3,264</p></td><td><p>4,054</p></td><td><p>3,584</p></td><td><p>3,503</p></td><td><p>3,640</p></td></tr></tbody></table><p> </p><p>Source: Hospital Episode Statistics (HES), NHS Digital</p><p>Notes:</p><p><sup>1</sup>The following attendance category codes identify unplanned A&amp;E attendances:</p><p>1 = First A&amp;E attendance</p><p>3 = Follow-up A&amp;E attendance – unplanned</p><p>9 = Not known</p><p><sup>2</sup>Attendance disposal 01 = Admitted to hospital bed / become a lodged patient of the same health care provider.</p><p><sup>3</sup>A&amp;E Diagnosis - The recording of the diagnosis field within the A&amp;E data set is not mandatory. It is not known to what extent changes over time are as a result of improvements in recording practice.</p><p>04 = Head injury</p><p><sup>4</sup>HES figures are available from 2007-08 onwards. Changes to the figures over time need to be interpreted in the context of improvements in data quality and coverage and changes in NHS practice. For example, changes in activity may be due to changes in the provision of care. Note that HES include activity ending in the year in question and run from April to March, e.g. 2012-13 includes activity occurring between 1 April 2012 and 31 March 2013.</p><p> </p> answering member constituency Ludlow answering member printed Mr Philip Dunne question first answered 31/10/2017 12:18:18 answering member 1542 label Biography information for Philip Dunne
tabling member	4663 label Biography information for Ben Bradley

713494

registered interest
date	23/03/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Familial Hypercholesterolaemia
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, what steps his Department is taking to ensure that diagnosis and management of familial hypercholesterolaemia is consistent across England.
tabling member constituency	Mansfield
tabling member printed	Sir Alan Meale
uin	69039
answer	answer is ministerial correction date of answer 30/03/2017 answer text <p>NHS England and Public Health England are working to raise the profile of familial hypercholesterolaemia (FH) and break down the barriers to genetic testing. Specifically, FH is emphasised in the NHS England Prevention aide memoire to support Sustainability and Transformation Planning, which is available at:</p><p><a href="http://www.england.nhs.uk/wp-content/uploads/2016/05/stp-aide-memoire-prevention.pdf" target="_blank">www.england.nhs.uk/wp-content/uploads/2016/05/stp-aide-memoire-prevention.pdf</a></p><p> </p><p>NHS England’s National Clinical Director for heart disease chairs an FH steering group which comprises representatives from relevant stakeholder organisations, including Public Health England. This group, with funding from the British Heart Foundation, has established FH specialist nurses in many areas of England, aimed at increasing FH cascade testing across the country so that more affected families can be identified. The steering group aims to develop a systems approach to the detection and management of FH.</p><p> </p><p>One third of England is now covered by these FH nurses as well as cascade testing, and over the last three years more than 1,000 new people with FH have been identified.</p><p> </p><p>Software to support cascade testing and provide a database for FH is available and will be increasingly used in England as FH services are established.</p><p> </p><p>NHS England has also identified FH as a possible condition that it could focus on as part of the work looking into personalised medicine and how the NHS might make better use of increased genetic testing.</p><p> </p><p>Finally, a cholesterol test is included as part of the NHS Health Check that is mandated by the Health and Social Care Act for delivery across all local authorities in England. Revised NHS Best Practice Guidance published in February now includes strengthened guidance for detection of FH as part of the NHS Health Check. Every patient with a cholesterol test result above 7.5mmol/l (as per National Institute for Health and Care Excellence guidance) will be alerted to their general practitioner for consideration of FH in combination with other diagnostic criteria.</p> answering member constituency Oxford West and Abingdon answering member printed Nicola Blackwood grouped question UIN 69040 question first answered 30/03/2017 14:03:39 answering member 4019 label Biography information for Baroness Blackwood of North Oxford
tabling member	361 label Biography information for Sir Alan Meale

713495

registered interest
date	23/03/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Familial Hypercholesterolaemia
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, what steps his Department is taking to help all clinical commissioning groups to provide adequate access to genetic cascade testing services for familial hypercholesterolemia in their areas.
tabling member constituency	Mansfield
tabling member printed	Sir Alan Meale
uin	69040
answer	answer is ministerial correction date of answer 30/03/2017 answer text <p>NHS England and Public Health England are working to raise the profile of familial hypercholesterolaemia (FH) and break down the barriers to genetic testing. Specifically, FH is emphasised in the NHS England Prevention aide memoire to support Sustainability and Transformation Planning, which is available at:</p><p><a href="http://www.england.nhs.uk/wp-content/uploads/2016/05/stp-aide-memoire-prevention.pdf" target="_blank">www.england.nhs.uk/wp-content/uploads/2016/05/stp-aide-memoire-prevention.pdf</a></p><p> </p><p>NHS England’s National Clinical Director for heart disease chairs an FH steering group which comprises representatives from relevant stakeholder organisations, including Public Health England. This group, with funding from the British Heart Foundation, has established FH specialist nurses in many areas of England, aimed at increasing FH cascade testing across the country so that more affected families can be identified. The steering group aims to develop a systems approach to the detection and management of FH.</p><p> </p><p>One third of England is now covered by these FH nurses as well as cascade testing, and over the last three years more than 1,000 new people with FH have been identified.</p><p> </p><p>Software to support cascade testing and provide a database for FH is available and will be increasingly used in England as FH services are established.</p><p> </p><p>NHS England has also identified FH as a possible condition that it could focus on as part of the work looking into personalised medicine and how the NHS might make better use of increased genetic testing.</p><p> </p><p>Finally, a cholesterol test is included as part of the NHS Health Check that is mandated by the Health and Social Care Act for delivery across all local authorities in England. Revised NHS Best Practice Guidance published in February now includes strengthened guidance for detection of FH as part of the NHS Health Check. Every patient with a cholesterol test result above 7.5mmol/l (as per National Institute for Health and Care Excellence guidance) will be alerted to their general practitioner for consideration of FH in combination with other diagnostic criteria.</p> answering member constituency Oxford West and Abingdon answering member printed Nicola Blackwood grouped question UIN 69039 question first answered 30/03/2017 14:03:39 answering member 4019 label Biography information for Baroness Blackwood of North Oxford
tabling member	361 label Biography information for Sir Alan Meale

713503

registered interest
date	23/03/2017
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Genomics: Research
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, if he will provide an update on his Department's work on the 100,000 Genomes Project; and if he will make a statement.
tabling member constituency	Mansfield
tabling member printed	Sir Alan Meale
uin	69038
answer	answer is ministerial correction date of answer 31/03/2017 answer text <p>The 100,000 Genomes Project is making good progress. The project is at the leading edge of global science, developing ground breaking new techniques and protocols.</p><p> </p><p>Genomics England has developed semi-automated bioinformatics to analyse genomic data to find the cause of disease. To date, over 29,000 whole genomes have been sequenced and reports are already being returned to the National Health Service who are responsible for discussing clinical interpretations and next steps with patients.</p><p> </p><p>The project is already changing the lives of patients with a rare disease – providing many patients with diagnoses for the first time, often after years of uncertainty and distress whilst helping to reduce considerable costs to health and social care budgets.</p><p> </p><p>Genomics England and NHS England are actively developing a fast track pipeline for patients with cancer who are participating in the Project. We are aiming to reduce the time from sample acquisition to the return of a report to four weeks. This will increase the utility of the service to clinicians and patients alike.</p> answering member constituency Oxford West and Abingdon answering member printed Nicola Blackwood question first answered 31/03/2017 09:32:42 answering member 4019 label Biography information for Baroness Blackwood of North Oxford
tabling member	361 label Biography information for Sir Alan Meale