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date	2014-05-01
answer › answering member constituency	Battersea
uin	197463

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registered interest

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answering body

answering dept id

answering dept short name

answering dept sort name

house id

legislature


pref label

question text

tabling member constituency

tabling member printed

uin

answer

is ministerial correction

date of answer

exactly:

or between:
and

answer text

answering member constituency

answering member printed

grouped question UIN

question first answered

answering member


label

tabling member


label

49514

registered interest

date

01/05/2014

answering body

Department of Health

answering dept id

answering dept short name

Health

answering dept sort name

Health

house id

legislature

25259

pref label	House of Commons

question text

To ask the Secretary of State for Health, pursuant to the Answer of 7 April 2014, Official Report, column 42W, on in vitro fertilisation, if he will provide specific references to the available evidence that no genomic DNA is found in the mitochondria but only in the cell nucleus; how their consideration that mitochondrial DNA is not part of the genome relates to the presentation of data on the human genome in the ENSEMBL and OMIM databases; what precise genetic modifications are applied to the eggs or embryos that would prevent any nuclear DNA from the egg or embryo donors from being inherited by the resulting child; and if he will make a statement.

tabling member constituency

Southend West

tabling member printed

Mr David Amess

uin

197463

answer

is ministerial correction

date of answer

07/05/2014

answer text

We have been advised by the Wellcome Trust that whole mitochondrial DNA genome sequencing has revealed no evidence of nuclear genomic DNA inside mitochondria and data on the human genome available in the ENSEMBL and OMIM databases confirms that there is no nuclear genomic DNA in the mitochondria. Inheritance of nuclear DNA from the donor egg is prevented in the Maternal Spindle Transfer technique through the removal of the spindle from the donor egg. Given that the nuclear DNA in the form of condensed chromosomes is attached to the spindle, nuclear genomic DNA from the donor will be removed and not inherited by the resulting child. Techniques that allow the visualisation of condensed chromosomes in eggs are used to ensure that all the chromosomes are removed. For embryos used in the Pronuclear Transfer technique, the nuclear genomic DNA is enclosed within the nuclear membrane of the maternal (egg-derived) and paternal (sperm-derived) pronuclei. The donor nuclear genomic DNA will be removed when the pronuclei are removed. There is no universally agreed definition of genetic modification in humans. The Government has adopted a working definition for the purpose of taking forward the draft mitochondrial donation regulations, that genetic modification involves the germ-line modification of nuclear DNA that can be passed on to future generations. Therefore, the Government does not accept that mitochondrial donation amounts to genetic modification.

answering member constituency

Battersea

answering member printed

Jane Ellison

grouped question UIN

197061

question first answered

07/05/2014 12:00:00

answering member

3918

label	Biography information for Jane Ellison

tabling member

44

label	Biography information for Sir David Amess