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776820
unstar this property registered interest false more like this
star this property date less than 2017-10-24more like thismore than 2017-10-24
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty's Government, with regard to oocytes frozen for a patient's own use, in how many cases in each year since 2013 was more than one embryo transferred simultaneously to the uterus; and how many multiple pregnancies resulted. more like this
star this property tabling member printed
Lord Winston more like this
star this property uin HL2484 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-11-01more like thismore than 2017-11-01
star this property answer text <p>The information requested is shown in the following table:</p><p> </p><table><tbody><tr><td><p> </p></td><td colspan="2"><p>Includes only cycles where exclusively more than one embryo created from a frozen egg was transferred</p></td></tr><tr><td><p>Year of treatment</p></td><td><p>Treatment cycles</p></td><td><p>Multiple pregnancies</p></td></tr><tr><td><p>2013</p></td><td><p>50</p></td><td><p>3</p></td></tr><tr><td><p>2014</p></td><td><p>63</p></td><td><p>1</p></td></tr><tr><td><p>2015</p></td><td><p>85</p></td><td><p>7</p></td></tr><tr><td><p>2016</p></td><td><p>64</p></td><td><p>4</p></td></tr></tbody></table><p> </p><p><em>Note:</em> Data has been provided for the latest verified data period: up to 30 June 2016 for pregnancies.</p><p><em>Source: </em>The Human Fertilisation and Embryology Authority</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-11-01T16:59:11.16Zmore like thismore than 2017-11-01T16:59:11.16Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
1770
unstar this property label Biography information for Lord Winston more like this
776819
unstar this property registered interest false more like this
star this property date less than 2017-10-24more like thismore than 2017-10-24
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty's Government, in respect of oocytes frozen for a patient's own use, how many pregnancies, births, and miscarriages have resulted in each year since 2013, after the fertilisation of such oocytes in cases when those oocytes were collected and cryopreserved after the patient had reached the age of 35. more like this
star this property tabling member printed
Lord Winston more like this
star this property uin HL2483 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-11-01more like thismore than 2017-11-01
star this property answer text <p>The information requested is shown in the following table:</p><p> </p><table><tbody><tr><td><p> </p></td><td colspan="3"><p>Includes only cycles where exclusively embryos created from frozen eggs were transferred</p></td></tr><tr><td><p>Year of treatment</p></td><td><p>Pregnancies</p></td><td><p>Miscarriages</p></td><td><p>Live birth events</p></td></tr><tr><td><p>2013</p></td><td><p>5</p></td><td><p>2</p></td><td><p>3</p></td></tr><tr><td><p>2014</p></td><td><p>8</p></td><td><p>0</p></td><td><p>7<sup>1</sup></p></td></tr><tr><td><p>2015</p></td><td><p>9</p></td><td><p>0</p></td><td><p>3<sup>2</sup></p></td></tr><tr><td><p>2016</p></td><td><p>10<sup>3</sup></p></td><td><p>n/a</p></td><td><p>n/a</p></td></tr></tbody></table><p> </p><p><em>Notes:</em></p><p><sup>1</sup>The outcome of one reported pregnancy in 2014 has yet to be notified to the Human Fertilisation and Embryology Authority (HFEA) by the clinic that carried out the treatment cycle.</p><p><sup>2</sup>Data for births has been provided for the latest verified data period: up to 30 June 2015.</p><p><sup>3</sup>Data for pregnancies has been provided for the latest verified data period: up to 30 June 2016</p><p> </p><p><em>Source: </em>HFEA</p>
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-11-01T16:58:42.223Zmore like thismore than 2017-11-01T16:58:42.223Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
1770
unstar this property label Biography information for Lord Winston more like this
776821
unstar this property registered interest false more like this
star this property date less than 2017-10-24more like thismore than 2017-10-24
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty's Government how many of the oocytes frozen for a patient's own use in the UK since 2013 were frozen and thawed for the purpose of treatment by in vitro fertilisation; of those that were thawed, how many were successfully fertilised and appeared to develop normally; of those, how many were transferred to a uterus; and how many resulted in a live birth, a pregnancy, or a miscarriage. more like this
star this property tabling member printed
Lord Winston more like this
star this property uin HL2485 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-11-01more like thismore than 2017-11-01
star this property answer text <p>The information requested is shown in the following tables:</p><p> </p><table><tbody><tr><td><p> </p></td><td colspan="5"><p>Of all treatment cycles in that year</p></td></tr><tr><td><p>Year of treatment</p></td><td><p>Eggs stored for the patient’s own use</p></td><td><p>Eggs thawed</p></td><td><p>Eggs fertilised</p></td><td><p>Embryos developed</p></td><td><p>Embryos transferred</p></td></tr><tr><td><p>2013</p></td><td><p>5,944</p></td><td><p>895</p></td><td><p>337</p></td><td><p>317</p></td><td><p>143</p></td></tr><tr><td><p>2014</p></td><td><p>7,124</p></td><td><p>1,119</p></td><td><p>488</p></td><td><p>475</p></td><td><p>176</p></td></tr><tr><td><p>2015</p></td><td><p>10,259</p></td><td><p>1,623</p></td><td><p>737</p></td><td><p>706</p></td><td><p>223</p></td></tr><tr><td><p>2016</p></td><td><p>6,199</p></td><td><p>1,204</p></td><td><p>590</p></td><td><p>584</p></td><td><p>179</p></td></tr></tbody></table><p> </p><table><tbody><tr><td><p> </p></td><td colspan="3"><p>Of cycles where exclusively embryos created from frozen eggs were transferred</p></td></tr><tr><td><p>Year of treatment</p></td><td><p>Pregnancies</p></td><td><p>Miscarriages</p></td><td><p>Births</p></td></tr><tr><td><p>2013</p></td><td><p>20</p></td><td><p>6</p></td><td><p>15</p></td></tr><tr><td><p>2014</p></td><td><p>20</p></td><td><p>3</p></td><td><p>15</p></td></tr><tr><td><p>2015</p></td><td><p>31</p></td><td><p>0</p></td><td><p>11<sup>1</sup></p></td></tr><tr><td><p>2016</p></td><td><p>22<sup>2</sup></p></td><td><p>n/a</p></td><td><p>n/a</p></td></tr></tbody></table><p><em>Note:</em></p><p>Data has been provided for the latest verified data period:</p><p><sup>1</sup>Up to 30 June 2015 for births; and</p><p><sup>2</sup>Up to 30 June 2016 for pregnancies.</p><p><em>Source: </em>The Human Fertilisation and Embryology Authority</p>
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-11-01T16:02:50.997Zmore like thismore than 2017-11-01T16:02:50.997Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
1770
unstar this property label Biography information for Lord Winston more like this
776818
unstar this property registered interest false more like this
star this property date less than 2017-10-24more like thismore than 2017-10-24
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty's Government, in each year since 2008, what has been the incidence of (1) foetal abnormalities, and (2) autism or other neurological disorder, in birth or pregnancies resulting from the use of frozen oocytes after thawing and fertilisation. more like this
star this property tabling member printed
Lord Winston more like this
star this property uin HL2482 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-11-01more like thismore than 2017-11-01
star this property answer text <p>Information on the incidence of foetal abnormalities is shown in the following table:</p><p> </p><table><tbody><tr><td><p><strong> </strong></p></td><td><p>Includes only cycles where exclusively embryos created from frozen eggs were transferred</p></td></tr><tr><td><p>Year of treatment</p></td><td><p>Foetal abnormalities</p></td></tr><tr><td><p>2008</p></td><td><p>0</p></td></tr><tr><td><p>2009</p></td><td><p>1 (observed)</p></td></tr><tr><td><p>2010</p></td><td><p>0</p></td></tr><tr><td><p>2011</p></td><td><p>1 (uncertain)</p></td></tr><tr><td><p>2012</p></td><td><p>0</p></td></tr><tr><td><p>2013</p></td><td><p>0</p></td></tr><tr><td><p>2014</p></td><td><p>0</p></td></tr><tr><td><p>2015</p></td><td><p>0</p></td></tr></tbody></table><p> </p><p><em>Note:</em> Data has been provided for the latest verified data period: to 30 June 2015 for births.</p><p><em>Source: </em>The Human Fertilisation and Embryology Authority</p><p> </p><p>The Human Fertilisation and Embryology Authority (HFEA) has advised that since October 2007 it has only collected data where a congenital abnormality was reported as either observed or uncertain following a birth event. The HFEA has also advised that it does not collect information on the incidence of autism or other neurological disorders in births or pregnancies resulting from the use of frozen oocytes after thawing and fertilisation.</p>
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-11-01T16:00:47.173Zmore like thismore than 2017-11-01T16:00:47.173Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
1770
unstar this property label Biography information for Lord Winston more like this
768526
unstar this property registered interest false more like this
star this property date less than 2017-10-11more like thismore than 2017-10-11
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty's Government, further to the Written Answer by Lord Prior of Brampton on 22 November 2016 (HL3075), how many human embryos were transferred to uteri in order to establish pregnancies following (1) vitrification, and (2) slow freezing methods; how many human embryos were deliberately destroyed following (a) vitrification, and (b) slow freezing methods, in the last five years for which figures are available; and how many human embryos held in storage have been allocated for potential destruction, but have not yet been deliberately destroyed, in the last five years for which figures are available, following either (i) vitrification, or (ii) slow freezing methods. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL1882 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-10-24more like thismore than 2017-10-24
star this property answer text <p>The Human Fertilisation and Embryology Authority has advised that it does not hold information on the method of freezing.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-10-24T13:58:08.423Zmore like thismore than 2017-10-24T13:58:08.423Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
714921
unstar this property registered interest false more like this
star this property date less than 2017-03-29more like thismore than 2017-03-29
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, with reference to paragraphs 2.8, 2.9 and 3.17 of the minutes of 9 March 2017 of the Licence Committee of the Human Fertilisation and Embryology Authority, regarding the follow-up of children born following pronuclear transfer between embryos, who is responsible for the follow-up programme in NHS England; what health, genetic and epigenetic parameters are to be measured; what assessment they have made of the potential for long-term medical problems to only become evident after five years of age; whether they intend to conduct follow-ups beyond five years of age; and whether they will place in the Library of the House a copy of the full documented processes that are in place setting out how follow-ups will be carried out. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL6409 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-04-06more like thismore than 2017-04-06
star this property answer text <p>The Human Fertilisation and Embryology Authority has advised that the guidance on the follow up of any children born following mitochondrial donation is set out in paragraph 33.33 in Guidance Note 33 of the Authority’s code of practice. This requires the centre to have a documented process setting out how children born from mitochondrial donation will be followed up, where the patients have consented to follow-up. These should include long-term medical follow-up of the children born. A copy of Guidance Note 33 is attached.</p><p> </p><p>NHS England has agreed funding of £8 million over five years for an evaluative commissioning programme of mitochondrial donation, working closely with the partner organisations such as the Wellcome Trust.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-04-06T10:57:08.84Zmore like thismore than 2017-04-06T10:57:08.84Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property attachment
1
star this property file name CoP_June_2016_GN33.pdf more like this
star this property title Guidance Note 33 more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
714754
unstar this property registered interest false more like this
star this property date less than 2017-03-28more like thismore than 2017-03-28
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, with reference to paragraph 2.8 of the minutes of 9 March 2017 of the Licence Committee of the Human Fertilisation and Embryology Authority (HFEA) regarding babies born following pronuclear transfer between embryos, what procedures are in place to (1) identify whether a child born following pronuclear transfer is born with (a) a mitochondrial disease, (b) a genetic or epigenetic abnormality, (c) a birth defect, or (d) some other adverse outcome, (2) notify the HFEA in cases of any such adverse outcome, and (3) identify any such adverse outcome and notify the HFEA where consent for follow-up has not been granted. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL6374 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-04-06more like thismore than 2017-04-06
star this property answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that, as set out in Guidance Note 33 of the Authority’s code of practice, centres carrying out mitochondrial donation are required to have documented processes in place setting out how the health of children born from mitochondrial donation will be followed up. A copy of Guidance Note 33 is attached.</p><p> </p><p>If the centre becomes aware that any child born as a result of mitochondrial donation has a mitochondrial disease, birth defect, genetic abnormality or if there has been any other adverse outcome, the centre must report this to the HFEA in accordance with the adverse incidents requirements set out in Guidance Note 27 of the code of practice. A copy of Guidance Note 27 is attached.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property attachment
1
star this property file name CoP_June_2016_GN33.pdf more like this
star this property title Guidance Note 33 more like this
2
star this property file name CoP_June_2016_GN27.pdf more like this
star this property title Guidance Note 27 more like this
star this property question first answered
less than 2017-04-06T10:53:18.493Zmore like thismore than 2017-04-06T10:53:18.493Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
714753
unstar this property registered interest false more like this
star this property date less than 2017-03-28more like thismore than 2017-03-28
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, with reference to paragraph 2.3 of the minutes of 9 March 2017 of the Licence Committee of the Human Fertilisation and Embryology Authority, which non-CE marked reagents will be used by Centre 0017 for the purposes of treatment involving pronuclear transfer between embryos to prevent transmission of serious mitochondrial disease; which laboratories will test the non-CE marked reagents for sterility and toxicity; and why non-CE marked reagents are being used. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL6373 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-04-05more like thismore than 2017-04-05
star this property answer text <p>The Human Fertilisation and Embryology Authority has advised that it is a condition of a licence that CE marked medical devices must be used wherever possible. In the case of pronuclear transfer, there are no appropriate CE marked reagents, meaning that for treatment to take place, non-CE marked reagents must be used. In this case, the centre must adhere to paragraph 26.5 in Guidance Note 26 of the Authority’s code of practice, which states that if a centre modifies a CE marked product or uses a product “off label”, it must complete a risk assessment and validation to ensure the product is safe. A copy of the Guidance Note 26 is attached.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-04-05T14:18:48.383Zmore like thismore than 2017-04-05T14:18:48.383Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property attachment
1
star this property file name Guidance_Note_26_-_Equipment_and_materials.pdf more like this
star this property title Guidance Note 26 more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
714752
unstar this property registered interest false more like this
star this property date less than 2017-03-28more like thismore than 2017-03-28
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, following the award by the Licence Committee of the Human Fertilisation and Embryology Authority of a licence to Centre 0017 to carry out pronuclear transfer between embryos to prevent transmission of serious mitochondrial disease, what safeguards Centre 0017 has put in place to ensure that early pronuclear transfer will take place during treatment at precisely the same epigenetic stage in donor and recipient embryos, given the rapid rate of DNA demethylation and the different rates of embryo development at the early pronuclear stage. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL6372 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-04-05more like thismore than 2017-04-05
star this property answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised the expert panel considered all the evidence that it believed was relevant to the safety and efficacy of mitochondrial donation techniques. The panel did not make any recommendations relating to epigenetics and so the HFEA has placed no such requirements on centres wishing to offer mitochondrial donation.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-04-05T14:17:54.203Zmore like thismore than 2017-04-05T14:17:54.203Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
708681
unstar this property registered interest false more like this
star this property date less than 2017-03-06more like thismore than 2017-03-06
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answer by Lord O’Shaughnessy on 28 February (HL5495), whether, and if so when, the Human Fertilisation and Embryology Authority (HFEA) directly requested any evidence from Dr Valery Zukin or members of his team since publishing its report on 30 November 2016; what assessment it has made of that evidence; whether it has received any evidence from other researchers on pronuclear transfer as specifically applied to patient treatments in a clinical context, and if so, from whom; or if no evidence has been sought from individuals with clinical experience of pronuclear transfer, why the HFEA has not taken into consideration the arguments of those known to have such experience. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL5812 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2017-03-17more like thismore than 2017-03-17
star this property answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that the work of the expert panel was to consider evidence relating to the use of mitochondrial donation techniques for the prevention of serious mitochondrial disease. Dr Zukin’s work relates to the use of the pronuclear transfer donation technique for fertility reasons only and is, therefore, of limited relevance to the techniques permitted by The Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015. For that reason, neither the expert panel nor the HFEA have requested evidence directly from Dr Zukin.</p><p> </p><p>As the most recent expert panel report has made clear, the panel did consider an article reporting a pregnancy derived from human zygote pronuclear transfer published in Reproductive BioMedicine Online in August 2016.</p> more like this
star this property answering member printed Lord O'Shaughnessy more like this
star this property question first answered
less than 2017-03-17T11:44:41.027Zmore like thismore than 2017-03-17T11:44:41.027Z
star this property answering member
4545
star this property label Biography information for Lord O'Shaughnessy more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this