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166637
unstar this property registered interest false more like this
star this property date less than 2014-11-27more like thismore than 2014-11-27
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government when they intend to bring forward regulations which will permit the implantation of embryos free of harmful mitochondrial mutations into the uterus of women carrying such harmful mutations. more like this
star this property tabling member printed
Lord Walton of Detchant more like this
star this property uin HL3228 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-04more like thisremove minimum value filter
star this property answer text <p>The Government will update Parliament as soon as possible with regard to these regulations.</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-04T15:48:52.923Zmore like thismore than 2014-12-04T15:48:52.923Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
1716
unstar this property label Biography information for Lord Walton of Detchant more like this
167200
unstar this property registered interest false more like this
star this property date less than 2014-12-02more like thismore than 2014-12-02
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answer by Lord Wallace of Saltaire on 1 December (HL3088), what was the overall incidence of stillbirths from in vitro fertilisation pregnancies for the past decade following foetal reduction in either the first trimester or early in the second trimester that affected (1) the remaining twin from the same twin pregnancy, (2) one of the remaining triplets from the same pregnancy, and (3) both of the remaining triplets from the same pregnancy, according to data held by the Human Fertilisation and Embryology Authority. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3301 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-15more like thismore than 2014-12-15
star this property answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that in the decade preceding 31 December 2012, the HFEA register records one incidence of a still birth following an embryo reduction at week 13 in a twin pregnancy, and one incidence of a still birth following a double embryo reduction at 12 weeks in a triplet pregnancy. Within this time period there are no other records of incidences of still births following foetal reductions in multiple pregnancies taking place within the first 16 weeks of pregnancy.</p><p> </p><p> </p><p> </p><p>The first trimester has been taken as weeks 0-13 and ‘early in the second trimester’ as weeks 14-16.</p><p> </p><p> </p><p> </p><p>The HFEA has also advised that any records held on its register after 31 December 2012 are not yet verified.</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-15T12:14:38.72Zmore like thismore than 2014-12-15T12:14:38.72Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
167201
unstar this property registered interest false more like this
star this property date less than 2014-12-02more like thismore than 2014-12-02
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answers by Earl Howe on 17 November (HL2642) and on 2 December (HL2905), whether they consider that mutations affecting DNA Polymerase Gamma might in turn ever be potentially responsible for disease-associated mitochondrial DNA mutations such as those listed in Annex D of the "Mitochondrial Donation" consultation document; and if not, why not. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3302 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-15more like thismore than 2014-12-15
star this property answer text <p>We have been advised that there is no evidence to suggest that mutations affecting DNA polymerase gamma result in high levels of the mitochondrial DNA mutations responsible for the mitochondrial diseases listed in Annex D of the mitochondrial donation consultation document. As stated in my previous answer of 17 November 2014 (<em>Official Report</em>, col WA59), mitochondrial donation techniques would only be used for patients that have an inherited mitochondrial DNA mutation and could not be used for those diseases in which faulty mitochondria arise from a nuclear gene mutation.</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-15T12:29:26.53Zmore like thismore than 2014-12-15T12:29:26.53Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
167202
unstar this property registered interest false more like this
star this property date less than 2014-12-02more like thismore than 2014-12-02
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answer by Earl Howe on 2 December (HL2905), what was the empirical evidence upon which the Human Fertilisation and Embryology Authority based its recommendation regarding multi-foetal pregnancy reduction. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3303 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-15more like thismore than 2014-12-15
star this property answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that as stated in my Written Answer of 17 November 2014 (<em>Official Report</em>, Columns WA 60-61), when developing its policy on multiple births, the HFEA commissioned an Expert Group on Multiple Births after IVF (in vitro fertilisation), which concluded that the prevention of multiple pregnancies through single embryo transfer should be preferred to multifetal pregnancy reduction.</p><p> </p><p> </p><p> </p><p>The evidence this recommendation was based on is outlined in the Expert Group’s report, available on the HFEA’s website at:</p><p> </p><p> </p><p> </p><p><a href="http://www.hfea.gov.uk/docs/MBSET_report.pdf" target="_blank">http://www.hfea.gov.uk/docs/MBSET_report.pdf</a></p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-15T12:15:26.823Zmore like thismore than 2014-12-15T12:15:26.823Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
167898
unstar this property registered interest false more like this
star this property date less than 2014-12-04more like thismore than 2014-12-04
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answers by Earl Howe on 3 December 2013 (WA 36) and 3 December 2014 (HL3158), which were the relevant experts or international authorities with whom the Chief Medical Officer "had a lot of discussions"; which international authorities agreed with the Chief Medical Officer’s own assessment that no-one "has come up with a better definition"; how the new definition is being accordingly incorporated into the syllabus for biology students; and what are their views on the ontological propriety of the proposed redefinition of genetic modification on the basis that it "is not that that is what it is". more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3422 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-18more like thismore than 2014-12-18
star this property answer text <p>As stated in my Written Answer of 3 December 2014 (<em>Official Report</em>, Column WA270), the development of a working definition for genetic modification in humans was undertaken in order to bring clarity to the discussion around mitochondrial donation and is solely intended to be used in this context. There is no universally agreed definition of genetic modification in humans and the working definition devised for the debate on mitochondrial donation did not aim to establish one. The Chief Medical Officer was clear in her evidence to the House of Commons Science and Technology Select Committee on 22 October 2014 that the definition’s purpose is to clarify discussion of this issue.</p><p> </p><p>With regard to the discussions that took place in developing the working definition, in developing its position the Department, in consultation with the Department for Business, Innovation and Skills, also had discussions with the Wellcome Trust and the Nuffield Council on Bioethics.</p><p> </p>
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-18T15:55:41.183Zmore like thismore than 2014-12-18T15:55:41.183Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
168119
unstar this property registered interest false more like this
star this property date less than 2014-12-05more like thismore than 2014-12-05
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answers by Earl Howe on 30 October 2013 (WA 259), 26 November 2013 (WA 263), 3 December 2013 (WA 36) and 3 December 2014 (HL3158), whether they can provide specific examples of internationally authoritative sources using terms like "genetic modification," "GM" and "germline" in "rather mixed and odd ways"; and what assessment they have made of the consistency of such use compared to the consistency of their definition with sources they consider to be authoritative. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3461 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-16more like thismore than 2014-12-16
star this property answer text <p>As the noble Lord is aware, there is no universally agreed definition of genetic modification or “GM” in humans.</p><p> </p><p><strong> </strong></p><p> </p><p>The Human Fertilisation and Embryology Authority’s report of its public dialogue exercise referred to the mitochondrial donation techniques as “germ-line modification”, and the Nuffield Council on Bioethics’ review of Novel Techniques for the Prevention of Mitochondrial DNA Disorders referred to them as a form of “germ line gene therapy”. As the purpose of mitochondrial donation would be to prevent the transmission of serious mitochondrial disease from mother to child, we agree with this.</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-16T14:46:44.687Zmore like thismore than 2014-12-16T14:46:44.687Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
170257
unstar this property registered interest false more like this
star this property date less than 2014-12-15more like thismore than 2014-12-15
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answer by Earl Howe on 15 December (HL3301), how many foetal reductions performed following in vitro fertilisation over the past decade were performed between (1) weeks 0–5, (2) weeks 6–13, and (3) weeks 14–16. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3753 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2014-12-31more like thismore than 2014-12-31
star this property answer text <p>The Human Fertilisation and Embryology Authority has advised that in the decade preceding 31 December 2012, the Authority’s register records the following incidences of foetal reductions performed following in vitro fertilisation:</p><p> </p><p> </p><p> </p><table><tbody><tr><td><p>Foetal reduction in weeks 0-5</p></td><td><p>Foetal reduction in weeks 6-13</p></td><td><p>Foetal reduction in weeks 14-16</p></td></tr><tr><td><p>0</p></td><td><p>156</p></td><td><p>27</p></td></tr></tbody></table><p> </p><p> </p><p> </p><p> </p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2014-12-31T11:13:26.747Zmore like thismore than 2014-12-31T11:13:26.747Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
170258
unstar this property registered interest false more like this
star this property date less than 2014-12-15more like thismore than 2014-12-15
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answer by Earl Howe on 15 December (HL3302), how exhaustively the POLG gene at chromosomal locus 15q25 has been sequenced in all individuals known to be affected by the mitochondrial diseases listed in Annex D of the mitochondrial donation consultation document in order to establish the evidence base described in that answer; and whether the Human Fertilisation and Embryology Authority would routinely require sequencing of the POLG gene in order to ensure that pronuclear transfer or spindle-chromosomal transfer should only be used for patients who have an inherited mitochondrial DNA mutation and not where faulty mitochondria may have arisen from a nuclear gene mutation. more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3754 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2015-01-05more like thismore than 2015-01-05
star this property answer text <p>We are advised by the Wellcome Trust that diagnosis of mitochondrial DNA disease is performed within the National Health Service Highly Specialised Service diagnostic laboratory using well established diagnostic algorithms and Practice Guidelines for the Molecular Diagnosis of Mitochondrial Diseases published by the Clinical Molecular Genetics Society at:</p><p> </p><p> </p><p> </p><p><a href="http://www.acgs.uk.com/media/774654/mito_2008.pdf" target="_blank">http://www.acgs.uk.com/media/774654/mito_2008.pdf</a></p><p> </p><p> </p><p> </p><p>Mitochondrial defects that arise due to nuclear gene mutations, such as DNA polymerase gamma, routinely give rise to multiple different mutations of mitochondrial DNA within patient tissues or depletion of mitochondrial DNA. This is apparent upon genetic testing and would then lead to analysis of the DNA polymerase gamma gene to identify the nuclear gene defect.</p><p> </p><p> </p><p> </p><p>The Human Fertilisation and Embryology Authority has advised that it will design the regulatory process following the passage of any regulations to allow mitochondrial donation. Should Parliament pass the mitochondrial donation regulations, the technique could only be licensed for the avoidance of diseases caused by inherited mutations in mitochondrial DNA, not nuclear DNA.</p><p> </p>
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2015-01-05T12:41:56.203Zmore like thismore than 2015-01-05T12:41:56.203Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property attachment
1
star this property file name CMGS Practice Guidelines for the Molecular Diagnosis of Mitochondrial Diseases.pdf more like this
star this property title CMGS Practice Guidelines more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
170932
unstar this property registered interest false more like this
star this property date less than 2014-12-17more like thismore than 2014-12-17
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answers by Earl Howe on 30 October 2013 (WA 259), 26 November 2013 (WA 263), 3 December 2013 (WA 36), 3 December 2014 (HL3158) and 16 December 2014 (HL3461), whether they consider there to be any barriers to a universally agreed definition of genetic modification, in the light of the Chief Medical Officer’s views on the matter; if so, what are the "rather mixed and odd ways" in which others have used terms like "genetic modification," "GM" and "germline"; and how the statements by the Human Fertilisation and Embryology Authority and the Nuffield Council on Bioethics are consistent with their view that "this process is not genetic modification". more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3839 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2015-01-05more like thismore than 2015-01-05
star this property answer text <p>The Human Fertilisation and Embryology Authority refers to the proposed mitochondrial donation techniques as “germ-line modification” and the Nuffield Council on Bioethics as “germ line gene therapy”. As I stated in my Written Answer of 16 December 2014 (HL3461), we agree with this and believe it to be consistent with our view that the proposed mitochondrial donation techniques are not genetic modification.</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2015-01-05T14:55:56.067Zmore like thismore than 2015-01-05T14:55:56.067Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this
172309
unstar this property registered interest false more like this
star this property date less than 2015-01-06more like thismore than 2015-01-06
star this property answering body
Department of Health more like this
star this property answering dept id 17 more like this
star this property answering dept short name Health more like this
star this property answering dept sort name Health more like this
unstar this property hansard heading In Vitro Fertilisation remove filter
star this property house id 2 more like this
star this property legislature
25277
star this property pref label House of Lords more like this
star this property question text To ask Her Majesty’s Government, further to the Written Answers by Earl Howe on 30 October 2013 (WA 259), 26 November 2013 (WA 263), 3 December 2013 (WA 36), 3 December 2014 (HL3158), 16 December 2014 (HL3461) and 5 January (HL3839), whether the Chief Medical Officer’s views are the only obstacle they are aware of to a universally agreed definition of genetic modification; if not, what are the "rather mixed and odd ways" in which others have used terms like "genetic modification," "GM" and "germline". more like this
star this property tabling member printed
Lord Alton of Liverpool more like this
star this property uin HL3892 more like this
star this property answer
answer
unstar this property is ministerial correction false more like this
star this property date of answer less than 2015-01-20more like thismore than 2015-01-20
star this property answer text <p>I have nothing to add to the information I gave the noble Lord in my Written Answers of 16 December 2014 (<a href="http://www.parliament.uk/business/publications/written-questions-answers-statements/written-questions-answers/?page=1&amp;max=20&amp;questiontype=AllQuestions&amp;house=commons%2clords&amp;uin=3461" target="_blank">HL3461</a>) and 6 January 2015 (<a href="http://www.parliament.uk/business/publications/written-questions-answers-statements/written-questions-answers/?page=1&amp;max=20&amp;questiontype=AllQuestions&amp;house=commons%2clords&amp;uin=3839" target="_blank">HL3839</a>).</p><p> </p> more like this
star this property answering member printed Earl Howe more like this
star this property question first answered
less than 2015-01-20T11:56:34.36Zmore like thismore than 2015-01-20T11:56:34.36Z
star this property answering member
2000
star this property label Biography information for Earl Howe more like this
star this property tabling member
738
unstar this property label Biography information for Lord Alton of Liverpool more like this