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<p>Following reengineering of tumour provision to fresh tissue supply and creating
300 pathways for tumour supply across the 13 NHS Genomic Medicine Centres (GMCs),
Genomics England has continued to work with the National Health Service to improve
throughput over the life of the programme.</p><p>Over the past six months, the average
(median) turnaround time for cancer cases from enrolment to return of analysis was
39 working days. For fast-tracked and clinically urgent cases, this average over the
last six months is 25 working days. By September 2018, Genomics England were returning
samples at scale in 20 days or less demonstrating the improvements in the majority
of cases received.</p><p>The most clinically useful timeframe depends on each individual
patient’s clinical circumstances. As the 100,000 Genomes Project is a research programme,
patients were all offered the NHS standard of care for their condition, in addition
to Whole Genome Sequencing, so their therapy could proceed as rapidly as needed. During
the 100,000 Genomes Project about half of the cancer cases in the Project contained
actionable findings identifying a potential targeted therapy or clinical trial opportunity.</p><p>To
date, 5,801 participants results have been returned to NHS GMCs (some participants
have multiple reports). In total, 506 participants in the 100,000 Genomes Project,
many of whom had advanced disease at the time of enrolment, died before Genomics England
returned a whole genome analysis to the NHS. Of these, 176 were participants who died
before their DNA samples were received by Genomics England. In many cases the deceased
cancer participants became part of the Project via consent by a nominated representative,
relative or friend because of the value for research to help others even though it
was too late for the individual concerned.</p>
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