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172443

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Ebola
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, pursuant to his Statement of 5 January 2015, Official Report, columns 38-40, on UK Ebola preparedness, whether the eligibility for full access to NHS care will be retained by UK citizens working with aid agencies and international relief organisations outside the UK.
tabling member constituency	Sheffield, Brightside and Hillsborough
tabling member printed	Mr David Blunkett
uin	219990
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>United Kingdom citizens working with aid agencies and international relief organisations outside the UK, who remain ordinarily resident in the UK, will retain full entitlement to free NHS hospital treatment. For those not ordinarily resident in the UK, they will become so if they take up or resume settled residence in the UK, and will consequently be fully entitled again.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 15:15:15 answering member 3918 label Biography information for Jane Ellison
tabling member	395 label Biography information for Lord Blunkett

172529

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, pursuant to the Written Statement WS132 of 17 December 2014 on mitochondrial donation, whether the expert panel convened by the Human Fertilisation and Embryology Authority regarding mitochondrial transfer found that no females born following spindle-chromosomal complex transfer or pronuclear transfer would ever transmit the disease to subsequent generations.
tabling member constituency	Congleton
tabling member printed	Fiona Bruce
uin	220129
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>The principle behind the treatment is that the mitochondrial DNA that the child will inherit will be the disease-free mitochondrial DNA of the donor, not the faulty mitochondrial DNA of their mother. Although there is a small possibility that a low level of unhealthy mitochondria may be carried over when the patient’s nuclear DNA is moved from her egg or embryo to the donor’s, evidence continues to be reassuring that carry-over after mitochondrial replacement is very low and unlikely to be problematic. Therefore, the risks of mitochondrial disease being present in the subsequent generation will be low.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison grouped question UIN 220108 question first answered 12/01/2015 17:43:57 answering member 3918 label Biography information for Jane Ellison
tabling member	3958 label Biography information for Fiona Bruce

172530

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, with reference to the letter from the Parliamentary Under-Secretary of State for Public Health to Lord Alton of Liverpool of 30 October 2014, if he will place in the Library a full copy of the correspondence between members of the expert panel convened by the Human Fertilisation and Embryology Authority and the Zhang research group referred to in that letter.
tabling member constituency	Congleton
tabling member printed	Fiona Bruce
uin	220130
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that neither its members or executive have been in correspondence with the authors of the abstract referred to. However, a member of the Expert Panel convened by the HFEA had an email exchange with one of the authors regarding this abstract, which confirmed that the research group did not publish any further detail or follow up to this study. It would not be appropriate for a copy of this private correspondence to be placed in the Library.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 15:23:22 answering member 3918 label Biography information for Jane Ellison
tabling member	3958 label Biography information for Fiona Bruce

172532

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	Perinatal Mortality
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, what the average incidence was of stillbirths and linked infant deaths in England and Wales in which all of the twins or triplets from the same pregnancy that remained after foetal reduction in either the first trimester or early in the second trimester subsequently died in infancy or were stillborn in each of the last 10 years.
tabling member constituency	Congleton
tabling member printed	Fiona Bruce
uin	220131
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>This information is not collected centrally.</p> answering member constituency Central Suffolk and North Ipswich answering member printed Dr Daniel Poulter question first answered 12/01/2015 15:22:11 answering member 3932 label Biography information for Dr Dan Poulter
tabling member	3958 label Biography information for Fiona Bruce

172533

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, what the outcome of the Human Fertilisation and Embryology Authority's (HFEAs) comparisons between the development of embryos generated by pronuclear transfer using normally-fertilised human oocytes and that of normal ICSI-fertilised human oocytes was; when and for what reasons those experiments were originally deemed by the HFEA's expert review panel in the publication Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception, published in April 2011, to be critical before the technique could be assessed as safe to use clinically; and in which open access journal the relevant findings of that research were available immediately on publication following peer-review.
tabling member constituency	Stoke-on-Trent South
tabling member printed	Robert Flello
uin	220135
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>The Human Fertilisation and Embryology Authority (HFEA) has advised that the outcomes of the Expert Panel’s comparison, based on unpublished findings made available to the Panel, are outlined at paragraph 2.2.5 of the Panel’s 2013 report and paragraph 3.4.3 of the Panel’s 2014 report, which are available on the HFEA’s website at:</p><p> </p><p> </p><p> </p><p><a href="http://www.hfea.gov.uk/8806.html" target="_blank">http://www.hfea.gov.uk/8806.html</a></p><p> </p><p> </p><p> </p><p>and</p><p> </p><p> </p><p> </p><p><a href="http://www.hfea.gov.uk/8807.html" target="_blank">http://www.hfea.gov.uk/8807.html</a></p><p> </p><p> </p><p> </p><p>The reasons for deeming “pronuclear transfer using normally-fertilised human oocytes and development compared to normal ICSI (<em>Intracytoplasmic sperm injection</em>)-fertilised human oocytes” to be critical are outlined at paragraph 4.2.4 of the 2011 report, which are available on the HFEA’s website at:</p><p> </p><p> </p><p> </p><p>http://www.hfea.gov.uk/6372.html</p><p> </p><p> </p><p> </p><p>The Expert Panel convened by the HFEA first deemed this to be critical in April 2011, when this, its first report, was written.</p><p> </p><p> </p><p> </p><p>As stated in the Panel’s 2014 report “Experiments comparing PNT using normally-fertilised human oocytes with normal ICSI fertilised human oocytes appear to be well underway, but their results will need assessing before they can be incorporated into future recommendations.” At the time of writing, to the Panel’s knowledge the findings had not been published in an open access journal.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 17:07:43 answering member 3918 label Biography information for Jane Ellison
tabling member	1569 label Biography information for Robert Flello

172534

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, whether the experiments recommended by the Human Fertilisation and Embryology Authority's expert review panel in the publication, Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception, published in April 2011, on the removal of the spindle or pronuclei and placing it back into the oocyte to show the effect of the maternal spindle transfer and pronuclear manipulation techniques has been concluded; and in which peer-reviewed journal his Department plans to publish the findings of those experiments.
tabling member constituency	Stoke-on-Trent South
tabling member printed	Robert Flello
uin	220102
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>We are advised that good progress is being made with the experiments recommended by the Expert Panel convened by the Human Fertilisation and Embryology Authority (HFEA) and that the scientists involved hope to be able to provide an update shortly.</p><p> </p><p> </p><p> </p><p>The HFEA has advised that in their 2013 and 2014 reports the expert panel convened by the HFEA deemed these experiments to no longer be necessary, given the successful development to blastocyst stages after both Maternal Spindle Transfer (MST) and Pronuclear Transfer (PNT) with human oocytes and zygotes.</p><p> </p><p> </p><p> </p><p>The Department does not routinely publish scientific research conducted independently by others.</p><p> </p><p> </p><p> </p><p>Publications relating to the successful development to blastocyst stages after both MST and PNT with human oocytes and zygotes can be found in Nature.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 17:47:51 answering member 3918 label Biography information for Jane Ellison
tabling member	1569 label Biography information for Robert Flello

172535

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, whether the experiments recommended by the Human Fertilisation and Embryology Authority's expert review panel in the publications, Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception, published in April 2011, and Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception: update, published in March 2013, on karyotype analysis and comparative genomic hybridisation and copy number variation arrays of embryos derived from the maternal spindle transfer and pronuclear transfer technique therapies have been concluded; and in which peer-reviewed journal his Department plans to publish the findings of those experiments.
tabling member constituency	Stoke-on-Trent South
tabling member printed	Robert Flello
uin	220103
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>We are advised that good progress is being made with the experiments recommended by the Expert Panel convened by the Human Fertilisation and Embryology Authority (HFEA) and that the scientists involved hope to be able to provide an update shortly.</p><p> </p><p> </p><p> </p><p>The HFEA has advised that the following research has been completed for the Maternal Spindle Transfer technique:</p><p> </p><p> </p><p> </p><p>- karyotype analysis and comparative genomic hybridisation/copy number variation arrays of embryos derived from maternal spindle transfer; and</p><p> </p><p>- detailed analysis of epigenetic modifications and gene expression, with a range of markers for blastocyst cell types or embryos derived from maternal spindle transfer.</p><p> </p><p> </p><p> </p><p>The results were published in Nature in 2013 and further details were provided, in supplementary information from Mitalipov et al, to the Expert Panel convened by the Authority.</p><p> </p><p> </p><p> </p><p>At the time of writing the 2014 report, to the Panel’s knowledge the relevant results relating to Pronuclear Transfer technique had not been published in a peer-reviewed journal.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison grouped question UIN 220096 question first answered 12/01/2015 17:46:28 answering member 3918 label Biography information for Jane Ellison
tabling member	1569 label Biography information for Robert Flello

172536

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, pursuant to the Written Statement WS132 of 17 December 2014 on mitochondrial donation, for what reasons serial nuclear transfer is precluded by the proposed regulations 3(c) and 6(c) which prevent any further alterations in the nuclear or mitochondrial DNA.
tabling member constituency	Congleton
tabling member printed	Fiona Bruce
uin	220104
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>Regulations 3 and 6 of the Human Fertilisation and Embryology (Mitochondrial Donation) Regulations 2015 enable eggs and embryos created following the Maternal Spindle Transfer and the Pro-Nuclear Transfer techniques to be “permitted” for used in treatment subject to certain conditions (set out in regulations 4 and 7). Specifically, regulations 3 ( c ) and 6 ( c ) provide that no further alteration can be made to the egg or embryo that is created following mitochondrial donation. The intention is to ensure that mitochondrial donation, as allowed in the regulations, is a specifically defined process by which unhealthy mitochondria is replaced by healthy mitochondria.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 14:45:04 answering member 3918 label Biography information for Jane Ellison
tabling member	3958 label Biography information for Fiona Bruce

172537

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, if he will place in the Library the journal articles reporting the results of all the experiments recommended by the Human Fertilisation and Embryology Authority for testing the safety of the maternal spindle transfer technique and the pronuclear transfer technique in the publications Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception, published in April 2011, and Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception: update, published in March 2013.
tabling member constituency	Strangford
tabling member printed	Jim Shannon
uin	220114
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>All of the publications which the Expert Panel convened by the Human Fertilisation and Embryology Authority (HFEA) referred to in its 2011 and 2013 reviews are listed in the ‘evidence reviewed’ annexes of the reports. The non-confidential evidence submissions, where there are no copyright issues, are also available on the HFEA website: <a href="http://www.hfea.gov.uk/6372.html" target="_blank">http://www.hfea.gov.uk/6372.html</a></p><p> </p><p> </p><p> </p><p>We are advised by the HFEA that the Expert Panel’s scientific reviews do refer to both unpublished and peer reviewed published research. This has allowed the panel to take into account the very latest research on a confidential basis.</p><p> </p><p> </p><p> </p><p>Where unpublished research was referred to in earlier reports by the Panel, it has later been published. For example, much of the work of Dr Shoukhrat Mitalipov’s group (Oregon Health &amp; Science University) discussed with the panel in confidence was subsequently published in 2013 and 2014:</p><p> </p><p>- Tachibana M et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013 Jan 31;493(7434):627-31.</p><p> </p><p>- Tachibana M, et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell 2013 6;1228–1238</p><p> </p><p>- Mitalipov S et al. Limitations of preimplantation genetic diagnosis for mitochondrial DNA diseases. Cell Rep. 2014 May 22;7(4):935-7.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 17:44:30 answering member 3918 label Biography information for Jane Ellison
tabling member	4131 label Biography information for Jim Shannon

172538

registered interest
date	07/01/2015
answering body	Department of Health
answering dept id	17
answering dept short name	Health
answering dept sort name	Health
hansard heading	IVF
house id	1
legislature	25259 pref label House of Commons
question text	To ask the Secretary of State for Health, whether the experiments recommended by the Human Fertilisation and Embryology Authority's expert review panel in the publication, Scientific review of the safety and efficacy of methods to avoid mitochondrial disease through assisted conception, published April in 2011, on the use of maternal spindle transfer therapy on unfertilised human oocytes that have abnormal mitochondrial DNA has been concluded; and in which peer-reviewed journal his Department plans to make findings of those experiments available.
tabling member constituency	Stoke-on-Trent South
tabling member printed	Robert Flello
uin	220101
answer	answer is ministerial correction date of answer 12/01/2015 answer text <p>The Human Fertilisation and Embryology Authority has advised that in its 2014 report the Expert Panel concluded that the scientific justification for this set of experiments does not outweigh the ethical concerns about performing them. The Panel’s reasoning for this was:</p><p> </p><p> </p><p> </p><p>“Whilst it might be argued that it is useful to perform such a study, especially if any evidence arises to suggest a specific mtDNA mutation may have a replicative advantage, the panel recognises that it may be impractical to obtain sufficient numbers of oocytes or zygotes with mutant mtDNA for research.”</p><p> </p><p> </p><p> </p><p>At the time of writing the 2014 report, to the Panel’s knowledge, this work had not been published in a peer-reviewed journal.</p><p> </p> answering member constituency Battersea answering member printed Jane Ellison question first answered 12/01/2015 15:26:38 answering member 3918 label Biography information for Jane Ellison
tabling member	1569 label Biography information for Robert Flello